129254-37-1

Basic information

• Product Name: 1a-Acetyl-7-demethoxy-6-demethyl-7,7-(ethylenedioxy)-6,7-dihydro-6-((p-methoxyphenyl)thio)mitomycin A
• Synonyms: 1a-Acetyl-7-demethoxy-6-demethyl-7,7-(ethylenedioxy)-6,7-dihydro-6-((p-methoxyphenyl)thio)mitomycin A
• CAS NO: 129254-37-1
• Molecular Weight: 545.57
• Mol File: 129254-37-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1a-Acetyl-7-demethoxy-6-demethyl-7,7-(ethylenedioxy)-6,7-dihydro-6-((p-methoxyphenyl)thio)mitomycin A(CAS DataBase Reference)
• NIST Chemistry Reference: 1a-Acetyl-7-demethoxy-6-demethyl-7,7-(ethylenedioxy)-6,7-dihydro-6-((p-methoxyphenyl)thio)mitomycin A(129254-37-1)
• EPA Substance Registry System: 1a-Acetyl-7-demethoxy-6-demethyl-7,7-(ethylenedioxy)-6,7-dihydro-6-((p-methoxyphenyl)thio)mitomycin A(129254-37-1)

Safety Data

• Hazardous Substances Data: 129254-37-1(Hazardous Substances Data)

Upstream product

• 122644-74-0 1a-acetyl-7-demethoxy-6,7-dihydro-7,7-(ethylenedioxy)-6-(phenylselenyl)mitomycin A 
• 696-63-9 4-Methoxybenzenethiol 
• 1950-65-8 4-methoxybenzenesulfenyl chloride 
• 122644-75-1 6-Demethyl-7,7-(ethylenedioxy)-6,7-dihydro-6-methylidenemitosane 

Relevant articles and documents

6-Demethyl-6-halo- and 6-Demethyl-6-thiomitomycins: Synthesis of Novel Mitomycin Derivatives Involving a Tandem Michael Addition/Retro-Mannich Reaction Sequence

Synthesis of novel 6-demethyl-6-halomitomycins (3, 4, 6, and 7) and 6-demethyl-6-thiomytomycins (5 and 8) is described from key intermediates, namely, 6-demethyl-7,7-(ethylenedioxy)-6,6-dihalo-6,7-dihydromitosanes (18 and 19) and 6-demethyl-7,7-(ethylenedioxy)-6,7-dihydro-6-thiomitosane (20), respectively.Compounds 18-20 were prepared through a tandem Michael addition and a retro-Mannich reaction sequence (N-halosucinimide or cationic arylsulfenyl species in the presence of Et2NH) on 10.