1292799-35-9

Upstream product

• 267-48-1 5,6-methylenedioxyindole 
• 261959-40-4 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difuorophenyl)-3-(N-methylamino)-2-propanol 
• 1292799-34-8 5-(tert-butoxycarbonyl)-1,3-dioxolo[4,5-f]indole-7-carbaldehyde 
• 101966-88-5 5H-1,3-dioxolo[4,5-f ]indole-7-carbaldehyde 

Downstream Products

• 1292799-38-2 1-{[(5H-1,3-dioxolo[4,5-f]indol-7-yl)methyl]methylamino}-2-(2,4-difluorophenyl)-3-(1H-1,2,4-triazol-1-yl)propan-2-ol 

Relevant academic research and scientific papers

Synthesis and in vitro antifungal evaluation of 2-(2,4-difluorophenyl)-1- [(1H-indol-3-ylmethyl)methylamino]-3-(1H-1,2,4-triazol-1-yl)propan-2-ols

We extended our previous studies based on the design of 1-[(1H-indol-5-ylmethyl)amino]-2-phenyl-3-(1H-1,2,4-triazol-1-yl)propan-2-ols as antifungal agents toward the identification of new indol-3-ylmethylamino derivatives. The majority of these compounds exhibited antifungal activity against a Candida albicans strain (minimum inhibitory concentrations ranging from 199.0 to 381.0ng/mL) suggesting an inhibition of 14α-demethylase by sterol analysis studies, but are weaker inhibitors compared to their indol-5-ylmethylamino analogs.