220428-23-9

Basic information

• Product Name: (S)-3,3-dichloro-5-(2-(methoxymethyl)pyrrolidin-1-ylsulfonyl)indolin-2-one
• Synonyms: (S)-3,3-dichloro-5-(2-(methoxymethyl)pyrrolidin-1-ylsulfonyl)indolin-2-one
• CAS NO: 220428-23-9
• Molecular Weight: 379.264
• Mol File: 220428-23-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-3,3-dichloro-5-(2-(methoxymethyl)pyrrolidin-1-ylsulfonyl)indolin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-3,3-dichloro-5-(2-(methoxymethyl)pyrrolidin-1-ylsulfonyl)indolin-2-one(220428-23-9)
• EPA Substance Registry System: (S)-3,3-dichloro-5-(2-(methoxymethyl)pyrrolidin-1-ylsulfonyl)indolin-2-one(220428-23-9)

Safety Data

• Hazardous Substances Data: 220428-23-9(Hazardous Substances Data)

Upstream product

• 93783-15-4 3,3-dichloro-2-oxoindoline-5-sulfonyl chloride 
• 63126-47-6 (2S)-2-(methoxymethyl)-1-pyrrolidine 

Downstream Products

• 1292809-57-4 (S)-1-((1-(biphenyl-4-yl)-1H-1,2,3-triazol-5-yl)methyl)-5-(2-(methoxymethyl)pyrrolidin-1-ylsulfonyl)indoline-2,3-dione 
• 1292809-49-4 (S)-1-((1-(biphenyl-4-yl)-1H-1,2,3-triazol-4-yl)methyl)-5-(2-(methoxymethyl)pyrrolidin-1-ylsulfonyl)indoline-2,3-dione 
• 1292809-58-5 (S)-5-(2-(methoxymethyl)pyrrolidin-1-ylsulfonyl)-1-((1-(4-nitrophenyl)-1H-1,2,3-triazol-5-yl)methyl)indoline-2,3-dione 
• 1292809-50-7 (S)-5-(2-(methoxymethyl)pyrrolidin-1-ylsulfonyl)-1-((1-(4-nitrophenyl)-1H-1,2,3-triazol-4-yl)methyl)indoline-2,3-dione 
• 1292809-51-8 (S)-5-(2-(methoxymethyl)pyrrolidin-1-ylsulfonyl)-1-((1-(4-(trifluoromethyl)phenyl)-1H-1,2,3-triazol-4-yl)methyl)indoline-2,3-dione 
• 1292809-59-6 (S)-5-(2-(methoxymethyl)pyrrolidin-1-ylsulfonyl)-1-((1-(4-(trifluoromethyl)phenyl)-1H-1,2,3-triazol-5-yl)methyl)indoline-2,3-dione 
• 1292809-60-9 (S)-5-(2-(methoxymethyl)pyrrolidin-1-ylsulfonyl)-1-((1-(4-methoxyphenyl)-1H-1,2,3-triazol-5-yl)methyl)indoline-2,3-dione 
• 1292809-52-9 (S)-5-(2-(methoxymethyl)pyrrolidin-1-ylsulfonyl)-1-((1-(4-methoxyphenyl)-1H-1,2,3-triazol-4-yl)methyl)indoline-2,3-dione 
• 1292809-54-1 (S)-1-((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)-5-(2-(methoxymethyl)pyrrolidin-1-ylsulfonyl)indoline-2,3-dione 
• 1292809-62-1 (S)-1-((1-benzyl-1H-1,2,3-triazol-5-yl)methyl)-5-(2-(methoxymethyl)pyrrolidin-1-ylsulfonyl)indoline-2,3-dione 
• 1292809-55-2 (S)-5-(2-(methoxymethyl)pyrrolidin-1-ylsulfonyl)-1-(2-(1-phenyl-1H-1,2,3-triazol-4-yl)ethyl)indoline-2,3-dione 
• 1292809-63-2 (S)-5-(2-(methoxymethyl)pyrrolidin-1-ylsulfonyl)-1-(2-(1-phenyl-1H-1,2,3-triazol-5-yl)ethyl)indoline-2,3-dione 
• 1292809-48-3 (S)-5-(2-(methoxymethyl)pyrrolidin-1-ylsulfonyl)-1-((1-phenyl-1H-1,2,3-triazol-4-yl)methyl)indoline-2,3-dione 
• 1292809-56-3 (S)-5-(2-(methoxymethyl)pyrrolidin-1-ylsulfonyl)-1-((1-phenyl-1H-1,2,3-triazol-5-yl)methyl)indoline-2,3-dione 

Relevant articles and documents

Isatin 1,2,3-triazoles as potent inhibitors against caspase-3

Sixteen disubstituted 1,2,3-triazoles were prepared using the Huisgen cycloaddition reaction and evaluated as inhibitors against caspase-3. The two most potent inhibitors were found to be (S)-1-((1-(2,3-dihydrobenzo[b][1,4] dioxin-6-yl)-1H-1,2,3-triazol-4-yl)methyl)-5-((2-(methoxymethyl)pyrrolidin-1-yl) sulfonyl)indoline-2,3-dione (7f) and (S)-1-((1-benzyl-1H-1,2,3-triazol-5-yl) methyl)-5-((2-(methoxymethyl)pyrrolidin-1-yl)sulfonyl)indoline-2,3-dione (8g) with IC50-values of 17 and 9 nM, respectively. Lineweaver-Burk plots revealed that these two triazoles show competitive inhibitory mechanism against caspase-3.