1292817-44-7

Upstream product

• 626-39-1 1,3,5-trisbromobenzene 
• 2715-43-7 ethyl 4-vinylbenzoate 
• 1292817-47-0 1,3,5-tris[(1E)-2’-(ethyl 4’’-benzoate)vinyl]benzene 

Relevant academic research and scientific papers

A novel antimicrobial agent reduces oxidative stress in cells

1,3,5-Tris[(1E)-2′-(4″-benzoic acid)vinyl]benzene] (Ramizol) is a potent and non-toxic synthetic antimicrobial agent, and we now establish that it is also a potent inhibitor of reactive oxygen species (ROS) generation, with similar antioxidant activity to α-tocopherol (Vitamin E), which is a standard antioxidant drug. The results show that Ramizol decreases ROS to basal levels in PC12 cells and mouse and guinea pig myocytes, and demonstrate its protective nature from oxidative damage to the cells. The continuing challenge to discover antibiotics with no or few side effects makes Ramizol a very attractive candidate for the potential treatment of infections. The Royal Society of Chemistry 2013.

Inspiration from old dyes: Tris(stilbene) compounds as potent gram-positive antibacterial agents

Herein we describe the preparation and structure-activity relationship studies on range of stilbene based compounds and their antibacterial activity. Two related compounds, each bearing carboxylic acid moieties, exhibit good activity against several bacterial strains, including methicillin-resistant Staphylococcus aureus MRSA (ATCC 33592 and NCTC 10442). Compound 10 was most active against Moraxella catarrhalis with minimum inhibitory concentrations (MICs) of 0.12-0.25 μg mL-1 and against Staphylococcus spp. with MICs ranging from 2-4 μg mL-1. The derivative 17 showed increased activity with MICs of 0.06-0.25 μg mL-1 against M. catarrhalis and 0.12-1 against Staphylococcus spp. This level of activity is similar to that reported for S. aureus for antibiotics, such as vancomycin, with MICs of ≤2.0 μg mL-1 and clindamycin with MICs of ≤0.5 μg mL -1. As an indicator of toxicity, 17 was tested for its ability to lyse sheep erythrocytes, and showed low haemolytic activity. Such results highlight the value of tris(stilbene) compounds as antibacterial agents providing suitable properties for further development. Routes to new antibiotics: The preparation of and structure-activity relationship studies on a range of stilbene based compounds revealed two related compounds, each bearing carboxylic acid moieties, exhibiting pronounced activity against several bacterial strains including methicillin-resistant Staphylococcus aureus, MRSA (see scheme, dba = dibenzylidene acetone). Copyright

ANTIMICROBIAL COMPOUNDS

A compound for use as an antimicrobial having a formula (A).

The synthesis of fluorescent DNA intercalator precursors through efficient multiple heck reactions

A highly efficient synthesis of p-carboethoxy-tristyryl and carboethoxy-terastyrenyl benzene derivatives through a multiple Heck cross coupling reaction is reported. This reaction provides an efficient route to DNA intercalator precursors containing a benzene core. CSIRO 2011.