1292820-93-9Relevant academic research and scientific papers
Formylation of fluoroalkyl imines through visible-light-enabled H-atom transfer catalysis: Access to fluorinated α-amino aldehydes
Yang, Sen,Zhu, Shuangyu,Lu, Dengfu,Gong, Yuefa
supporting information, p. 2019 - 2024 (2019/04/10)
A visible-light-enabled catalytic formylation of fluoroalkyl imines is developed. With readily accessible starting materials and organocatalysts, this method provides a general approach to masked fluoroalkyl amino aldehydes. A synergistic catalytic effect
Highly diastereo- and enantioselective vinylogous Mannich reactions of fluorinated aldimines with siloxyfurans
Zhao, Qian-Yi,Yuan, Zhi-Liang,Shia, Min
supporting information; experimental part, p. 637 - 643 (2011/04/25)
A highly regio- and enantioselective asymmetric vinylogous Mannich reaction of readily available fluorinated aldimines bearing a chiral auxiliary [(S)-1-phenylethyl group] with siloxyfurans to afford chiral fluorine-containing γ-butenolide or γ-lactone derivatives has been developed in the presence of silver acetate (10 mol%) and axially chiral phosphine-oxazoline ligand L1 (11 mol%). In most cases, the corresponding fluorinated adducts were obtained in high yields, good to excellent enantiomeric excesses and up to > 20:1 dr.
