1292842-90-0

Basic information

• Product Name: (2-ethyl-6-hydroxybenzofuran-4-yl)(4-hydroxyphenyl)methanone
• Synonyms: (2-ethyl-6-hydroxybenzofuran-4-yl)(4-hydroxyphenyl)methanone
• CAS NO: 1292842-90-0
• Molecular Weight: 282.296
• Mol File: 1292842-90-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (2-ethyl-6-hydroxybenzofuran-4-yl)(4-hydroxyphenyl)methanone(CAS DataBase Reference)
• NIST Chemistry Reference: (2-ethyl-6-hydroxybenzofuran-4-yl)(4-hydroxyphenyl)methanone(1292842-90-0)
• EPA Substance Registry System: (2-ethyl-6-hydroxybenzofuran-4-yl)(4-hydroxyphenyl)methanone(1292842-90-0)

Safety Data

• Hazardous Substances Data: 1292842-90-0(Hazardous Substances Data)

Upstream product

• 100-07-2 4-methoxy-benzoyl chloride 
• 52814-92-3 1-(6-methoxybenzofuran-2-yl)ethan-1-one 
• 1292842-76-2 (2-ethyl-6-methoxybenzofuran-4-yl)(4-methoxyphenyl)methanone 
• 52814-93-4 2-ethyl-6-methoxybenzofuran 
• 673-22-3 2-Hydroxy-4-methoxybenzaldehyde 

Relevant articles and documents

Developing potent human uric acid transporter 1 (hURAT1) inhibitors

The kidneys are a vital organ in the human body. They serve several purposes including homeostatic functions such as regulating extracellular fluid volume and maintaining acid-base and electrolyte balance and are essential regarding the excretion of metabolic waste. Furthermore, the kidneys play an important role in uric acid secretion/reabsorption. Abnormalities associated with kidney transporters have been associated with various diseases, such as gout. The current study utilized Xenopus oocytes expressing human uric acid transporter 1 (hURAT1; SLC22A12) as an in vitro method to investigate novel compounds and their ability to inhibit 14C-uric acid uptake via hURAT1. We have prepared and tested a series of 2-ethyl-benzofuran compounds and probed the hURAT1 in vitro inhibitor structure-activity relationship. As compared to dimethoxy analogues, monophenols formed on the C ring showed the best in vitro inhibitory potential. Compounds with submicromolar (i.e., IC 50 1000 nM) inhibitors were prepared by brominating the corresponding phenols to produce compounds with potent uricosuric activity.