1292850-39-5

Basic information

• Product Name: N-{4-chloro-2-[hydroxy(3-methoxyphenyl)methyl]-phenyl}-2,2-dimethylpropanamide
• Synonyms: N-{4-chloro-2-[hydroxy(3-methoxyphenyl)methyl]-phenyl}-2,2-dimethylpropanamide
• CAS NO: 1292850-39-5
• Molecular Weight: 347.842
• Mol File: 1292850-39-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-{4-chloro-2-[hydroxy(3-methoxyphenyl)methyl]-phenyl}-2,2-dimethylpropanamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-{4-chloro-2-[hydroxy(3-methoxyphenyl)methyl]-phenyl}-2,2-dimethylpropanamide(1292850-39-5)
• EPA Substance Registry System: N-{4-chloro-2-[hydroxy(3-methoxyphenyl)methyl]-phenyl}-2,2-dimethylpropanamide(1292850-39-5)

Safety Data

• Hazardous Substances Data: 1292850-39-5(Hazardous Substances Data)

Upstream product

• 106-47-8 4-chloro-aniline 
• 3282-30-2 pivaloyl chloride 
• 65854-91-3 N-(4-chlorophenyl)-2,2-dimethylpropionamide 
• 591-31-1 3-methoxy-benzaldehyde 

Downstream Products

• 1292850-40-8 {5-chloro-2-[(2,2-dimethylpropyl)amino]phenyl}-(3-methoxyphenyl)methanol 

Relevant articles and documents

Discovery of a new 2-aminobenzhydrol template for highly potent squalene synthase inhibitors

To obtain small and efficient squalene synthase inhibitors, a flexible 2-aminobenzhydrol open form structure was designed and showed potent inhibitory activity comparable to 4,1-benzoxazepin compounds. Further chemical modification led to the discovery of a novel template with a strong squalene synthase inhibitory activity, and its basic structure-activity relationship was revealed. The X-ray crystallographic data of compound 12 bound to the active site of squalene synthase provided an important insight into the binding mode of this alternative template that formed 11-membered ring conformations with an intramolecular hydrogen bond.