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129295-30-3

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129295-30-3 Usage

General Description

6-Fluoro-1H-indazole-3-carboxylic acid is a chemical compound with the formula C9H6FN3O2. It belongs to the class of indazole carboxylic acids and contains a fluorine atom attached to the indazole ring. 6-Fluoro-1H-indazole-3-carboxylic acid has potential applications in pharmaceutical research and drug development due to its unique structure and reactivity. It may be used as a building block for the synthesis of new pharmaceutical compounds or as a precursor for the preparation of biologically active molecules. The presence of the indazole ring and the carboxylic acid group in this compound makes it a promising candidate for further investigation in the field of medicinal chemistry.

Check Digit Verification of cas no

The CAS Registry Mumber 129295-30-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,9,2,9 and 5 respectively; the second part has 2 digits, 3 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 129295-30:
(8*1)+(7*2)+(6*9)+(5*2)+(4*9)+(3*5)+(2*3)+(1*0)=143
143 % 10 = 3
So 129295-30-3 is a valid CAS Registry Number.
InChI:InChI=1/C8H5FN2O2/c9-4-1-2-5-6(3-4)10-11-7(5)8(12)13/h1-3H,(H,10,11)(H,12,13)

129295-30-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 6-FLUORO-1H-INDAZOLE-3-CARBOXYLIC ACID

1.2 Other means of identification

Product number -
Other names F2167-0193

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:129295-30-3 SDS

129295-30-3Upstream product

129295-30-3Relevant articles and documents

Development of potent serotonin-3 (5-HT3) receptor antagonists. II. Structure-activity relationships of N-(1-benzyl-4-methylhexahydro-1H-1,4- diazepin-6-yl)carboxamides

Harada,Morie,Hirokawa,Terauchi,Fujiwara,Yoshida,Kato

, p. 1912 - 1930 (2007/10/03)

Our studies on 4-amino-5-chloro-2-ethoxybenzamides led to the discovery that the N-(1,4-dimethylhexahydro-1H-1,4-diazepin-6-yl)benzamide 9 and the 1- benzyl-4-methylhexahydro-1H-1,4-diazepine analogue 10 are potent serotonin-3 (5-HT3) receptor antagonists. Structure-activity relationship (SAR) studies on the influence of the aromatic nucleus of 9 and 10 upon inhibition of the von Bezold-Jarisch reflex in rats are described. Heteroaromatic rings such as pyrrole, thiophene, furan, pyridine, pyridaziae, 1,2-benzisoxazole, indole, quinoline, and isoquinoline rings showed weak 5-HT3 receptor antagonistic activity. Within this series, use of the 1H-indazole ring as an aromatic moiety led to a substantial increase of the activity; the 1H- indazolylcarboxamides 54, 57, 97, and 102 showed potent 5-HT3 receptor antagonistic activity. The optimal compound identified via extensive SAR studies was N-(1-benzyl-4-methylhexahydro-1H-1,4-diazepin-6-yl)-1H-indazole- 3-carboxamide (54), whose effect was superior to that of the corresponding benzamide 10 and essentially equipotent to those of ondansetron (1) and granisetron (4).

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