129295-30-3 Usage
Uses
Used in Pharmaceutical Research and Drug Development:
6-Fluoro-1H-indazole-3-carboxylic acid serves as a building block for the synthesis of new pharmaceutical compounds, leveraging its unique structural attributes to contribute to the creation of innovative medications. Its role in this application is to provide a foundation upon which more complex and potentially effective drug molecules can be constructed.
Used in Medicinal Chemistry:
As a precursor for the preparation of biologically active molecules, 6-Fluoro-1H-indazole-3-carboxylic acid is instrumental in the advancement of medicinal chemistry. Its presence in the synthesis process can lead to the development of compounds with enhanced biological activity, which is crucial for the discovery of new therapeutic agents.
Used in Chemical Synthesis:
6-Fluoro-1H-indazole-3-carboxylic acid is utilized in chemical synthesis processes, where its reactivity and structural features are harnessed to produce a variety of chemical entities. Its versatility in synthesis makes it a valuable component in the creation of diverse chemical libraries, which are essential for high-throughput screening and drug discovery efforts.
Check Digit Verification of cas no
The CAS Registry Mumber 129295-30-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,9,2,9 and 5 respectively; the second part has 2 digits, 3 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 129295-30:
(8*1)+(7*2)+(6*9)+(5*2)+(4*9)+(3*5)+(2*3)+(1*0)=143
143 % 10 = 3
So 129295-30-3 is a valid CAS Registry Number.
InChI:InChI=1/C8H5FN2O2/c9-4-1-2-5-6(3-4)10-11-7(5)8(12)13/h1-3H,(H,10,11)(H,12,13)
129295-30-3Relevant academic research and scientific papers
Development of potent serotonin-3 (5-HT3) receptor antagonists. II. Structure-activity relationships of N-(1-benzyl-4-methylhexahydro-1H-1,4- diazepin-6-yl)carboxamides
Harada,Morie,Hirokawa,Terauchi,Fujiwara,Yoshida,Kato
, p. 1912 - 1930 (2007/10/03)
Our studies on 4-amino-5-chloro-2-ethoxybenzamides led to the discovery that the N-(1,4-dimethylhexahydro-1H-1,4-diazepin-6-yl)benzamide 9 and the 1- benzyl-4-methylhexahydro-1H-1,4-diazepine analogue 10 are potent serotonin-3 (5-HT3) receptor antagonists. Structure-activity relationship (SAR) studies on the influence of the aromatic nucleus of 9 and 10 upon inhibition of the von Bezold-Jarisch reflex in rats are described. Heteroaromatic rings such as pyrrole, thiophene, furan, pyridine, pyridaziae, 1,2-benzisoxazole, indole, quinoline, and isoquinoline rings showed weak 5-HT3 receptor antagonistic activity. Within this series, use of the 1H-indazole ring as an aromatic moiety led to a substantial increase of the activity; the 1H- indazolylcarboxamides 54, 57, 97, and 102 showed potent 5-HT3 receptor antagonistic activity. The optimal compound identified via extensive SAR studies was N-(1-benzyl-4-methylhexahydro-1H-1,4-diazepin-6-yl)-1H-indazole- 3-carboxamide (54), whose effect was superior to that of the corresponding benzamide 10 and essentially equipotent to those of ondansetron (1) and granisetron (4).
