1293285-04-7

Basic information

• Product Name: 3-fluoro-2-(pyrimidin-2-yl)benzoic acid
• Synonyms: 3-fluoro-2-(pyrimidin-2-yl)benzoic acid
• CAS NO: 1293285-04-7
• Molecular Formula: C₁₁H₇FN₂O₂
• Molecular Weight: 218.1838832
• Mol File: 1293285-04-7.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-fluoro-2-(pyrimidin-2-yl)benzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-fluoro-2-(pyrimidin-2-yl)benzoic acid(1293285-04-7)
• EPA Substance Registry System: 3-fluoro-2-(pyrimidin-2-yl)benzoic acid(1293285-04-7)

Safety Data

• Hazardous Substances Data: 1293285-04-7(Hazardous Substances Data)

Upstream product

• 403-54-3 m-Fluorobenzonitrile 
• 624741-47-5 3-fluoro-2-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)benzonitrile 
• 1293285-05-8 3-fluoro-2-(pyrimidin-2-yl)benzonitrile 
• 916792-62-6 2-iodo-3-fluorobenzonitrile 

Downstream Products

• 1293283-20-1 2-(4,6-dimethylpyrimidin-2-yl)-5-[(3-fluoro-2-pyrimidin-2-ylphenyl)carbonyl]octahydropyrrolo[3,4-c]pyrrole 
• 1293939-86-2 3-(4,6-dimethylpyrimidin-2-yl)-8-{[3-fluoro-2-(pyrimidin-2-yl)phenyl]carbonyl}-(1S,6R)-3,8-diazabicyclo[4.2.0]octane 

Relevant articles and documents

SUBSTITUTED 7-AZABICYCLES AND THEIR USE AS OREXIN RECEPTOR MODULATORS

The present invention is directed to compounds of Formula I: wherein ring A is phenyl, naphihalenyl, pyridyl, quinolinyl, isoquinolinyl, imidazopyridyl, furanyi, tlisazolyl, isoxazolvl, pyrazolyl, imidazothiazolyi, benzimidazolyl, or indazolyi; R1 is H, alky], aikoxy, hydroxyalkylene, OH, halo, phenyl, triazolyl, oxazolyl, isoxazofyl, pyridyl, pyrimidinyl, pyrazinyl, pyridazmyl, piperazinyl, pyrazolyl, oxadiazolvl, pyrrolidinyl, thiophenyi, morpholinyl, or dialkyiamino; R2 is H, alkyl, aikoxy, hydroxyalkylene, or halo; Z is NH, N-alkyl, or O; R5 is pyridyl, pyrimidinyl, pyrazinyl, pyridazmyl, qumazolinyi, quinoxalinyl, pyrazolyl, benzoxazolyl, imidazopyrazinyl, triazolopyrazinyl, optionally substituted with a one or two substituents independently selected from the group consisting of alkyl, aikoxy, or halo; and n is 0 or 1, Methods of making the compounds of Formula 1 are also described. The invention also relates to pharmaceutical compositions comprising compounds of Formula I. Methods of using the compounds of the invention are also within the scope of the invention.

DISUBSTITUTED OCTAHY-DROPYRROLO [3,4-C] PYRROLES AS OREXIN RECEPTOR MODULATORS

Disubstituted octahydropyrrolo[3,4-c]pyrrole compounds are described, which are useful as orexin receptor modulators. Such compounds may be useful in pharmaceutical compositions and methods for the treatment of diseased states, disorders, and conditions mediated by orexin activity, such as insomnia.

FUSED HETEROCYCLIC COMPOUNDS AS OREXIN RECEPTOR MODULATORS

Disubstituted 3,8-diaza-bicyclo[4.2.0]octane and 3,6-diazabicyclo [3.2.0]heptane compounds are described, which are useful as orexin receptor modulators. Such compounds may be useful in pharmaceutical compositions and methods for the treatment of diseased states, disorders, and conditions mediated by orexin activity, such as insomnia.

DISUBSTITUTED OCTAHY - DROPYRROLO [3,4-C] PYRROLES AS OREXIN RECEPTOR MODULATORS

Disubstituted octahydropyrrolo[3,4-c]pyrrole compounds are described, which are useful as orexin receptor modulators. Such compounds may be useful in pharmaceutical compositions and methods for the treatment of diseased states, disorders, and conditions mediated by orexin activity, such as insomnia.

FUSED HETEROCYCLIC COMPOUNDS AS OREXIN RECEPTOR MODULATORS

Certain disubstituted 3,8-diaza-bicyclo[4.2.0]octane and 3,6-diazabicyclo [3.2.0]heptane are described, which are useful as orexin inhibitors. Such compounds may be useful in pharmaceutical compositions and methods for the treatment of diseased states, disorders, and conditions mediated by orexin activity, such as insomnia.