624741-47-5

Usage

Uses

Used in Organic Synthesis:
3-Fluoro-2-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)benzonitrile is used as a building block for the synthesis of complex organic molecules, leveraging its unique structure and reactivity to facilitate the formation of desired products.
Used in Medicinal Chemistry:
In the pharmaceutical industry, 3-Fluoro-2-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)benzonitrile is utilized as an intermediate for the production of various pharmaceuticals, contributing to the development of new drugs with potential therapeutic applications.
Used in Agrochemicals:
3-Fluoro-2-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)benzonitrile is also employed in the agrochemical sector as an intermediate for the synthesis of agrochemicals, aiding in the creation of effective compounds for crop protection and enhancement.
Used in Cross-Coupling Reactions:
3-Fluoro-2-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)benzonitrile is used as a reagent in cross-coupling reactions, particularly for the formation of carbon-carbon bonds. Its boron-containing ring system enhances the efficiency and selectivity of these reactions, which are crucial for the synthesis of a wide range of organic compounds.

Upstream product

• 73183-34-3 bis(pinacol)diborane 
• 425379-16-4 2-bromo-3-fluorobenzonitrile 

Downstream Products

• 765916-85-6 6,2'-difluoro-5'-[3-(2,4-difluorophenyl)-[1,2,4]triazin-5-yl]biphenyl-2-carbonitrile 
• 1293285-05-8 3-fluoro-2-(pyrimidin-2-yl)benzonitrile 
• 1293285-04-7 3-fluoro-2-(pyrimidin-2-yl)benzoic acid 

Relevant academic research and scientific papers

Efficient monophosphorus ligands for palladium-catalyzed miyaura borylation

In combination with the Bedford Pd precursor, the new biaryl monophosphorus ligand 5 was efficient for palladium-catalyzed Miyaura borylation of sterically hindered aryl bromides at low catalyst loadings.

IMIDAZO-TRIAZINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS

A class of 7-phenylimidazo[1,2-b][1,2,4]triazine derivatives, substituted at the meta position of the phenyl ring by an optionally substituted aryl or heteroaryl group which is directly attached or bridged by an oxygen atom or a -NH- linkage, and substituted on the phenyl ring by one or two further substituents as defined herein, being selective ligands for GABAA receptors, in particular having good affinity for the α2 and/or α3 and/or α5 subunit thereof, are accordingly of benefit in the treatment and/or prevention of adverse conditions of the central nervous system, including anxiety, convulsions and cognitive disorders.

IMIDAZO-PYRIDINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS

A class of 8-fluoro-3-phenylimidazo[1,2-a]pyridine derivatives, substituted at the meta position of the phenyl ring by an optionally substituted aryl or heteroaryl group, or by a pyrrolidinonyl group, which is directly attached or bridged by an oxygen atom or by a -NH- or -OCH2- linkage, being selective ligands for GABAA receptors, in particular having high affinity for the α2 and/or α3 and/or α5 subunit thereof, are accordingly of benefit in the treatment and/or prevention of adverse conditions of the central nervous system, including anxiety, convulsions and cognitive disorders.