129329-64-2

Upstream product

• 7205-91-6 phenylthiomethyl chloride 
• 138428-93-0 2-(phenylthiomethyl)butanamide 
• 138428-91-8 methyl 2-(phenylthiomethyl)butanoate 
• 79759-95-8 (3S*,4R*)-N-(tert-butyldimethylsilyl)-3-ethyl-4-(phenylthio)azetidin-2-one 
• 79759-95-8 (3S*,4S*)-N-(tert-butyldimethylsilyl)-3-ethyl-4-(phenylthio)azetidin-2-one 
• 79759-95-8 (3S)-1-(tert-butyldimethylsilyl)-3-ethyl-4-(phenylthio)azetidin-2-one 
• 79759-95-8 N-(tert-butyldimethylsilyl)-3-ethyl-4-(phenylthio)azetidin-2-one 

Downstream Products

• 137528-25-7 (3R*,4R*)-4-(benzyloxycarbonylmethyl)-3-ethylazetidin-2-one 
• 125606-80-6 (3R*,4R*)-4-(benzyloxycarbonylmethyl)-N-(tert-butyldimethylsilyl)-3-ethylazetidin-2-one 
• 141195-52-0 (3R,4R)-4-(benzyloxycarbonylmethyl)-3-ethylazetidin-2-one 
• 141195-51-9 (3R,4R)-4-(benzyloxycarbonylmethyl)-1-(tert-butyldimethylsilyl)-3-ethylazetidin-2-one 

Relevant academic research and scientific papers

Chemistry of O-silylated ketene acetals: A stereoselective synthesis of optically active carbapenem antibiotics, (+)-thienamycin and (+)-PS-5

A stereoselective synthesis of the chiral thienamycin intermediate (16) involving a diastereoselective Michael addition and a silicon-induced Pummerer-type reaction is described. In a similar way, the key intermediate for (+)-PS-5 was also prepared from 4

Chemistry of O-silylated ketene acetals: A mild and convenient synthesis of β-lactam antibiotics

β-Amido sulfoxides (1) reacted with O-silylated ketene acetal (16) in dry acetonitrile in the presence of a catalytic amount of zinc iodide to give the 4-phenylthioazetidin-2-ones (17). Oxidation of 17 with m-chloroperbenzoic acid gave the corresponding s