79759-95-8Relevant academic research and scientific papers
Chemistry of O-silylated ketene acetals: A stereoselective synthesis of optically active carbapenem antibiotics, (+)-thienamycin and (+)-PS-5
Kita,Shibata,Miki,Takemura,Tamura
, p. 12 - 20 (2007/10/02)
A stereoselective synthesis of the chiral thienamycin intermediate (16) involving a diastereoselective Michael addition and a silicon-induced Pummerer-type reaction is described. In a similar way, the key intermediate for (+)-PS-5 was also prepared from 4
Chemistry of O-silylated ketene acetals: A mild and convenient synthesis of β-lactam antibiotics
Kita,Shibata,Tamura,Miki
, p. 2225 - 2232 (2007/10/02)
β-Amido sulfoxides (1) reacted with O-silylated ketene acetal (16) in dry acetonitrile in the presence of a catalytic amount of zinc iodide to give the 4-phenylthioazetidin-2-ones (17). Oxidation of 17 with m-chloroperbenzoic acid gave the corresponding s
