1293306-05-4

Upstream product

• 75-77-4 chloro-trimethyl-silane 
• 414871-53-7 (3S,3aS,7aR)-2-(1-methyl-1-phenylethyl)-3-phenyl-2,3,3a,7a-tetrahydro-1H-isoindole-1,5(4H)-dione 
• 72659-59-7 lithium R-(-)-N-isopropyl-1-phenylethyl amide 

Downstream Products

• 1293306-08-7 (3S,3aS,7S,7aR)-3-phenyl-7-(trimethylsilyl)hexahydro-1H-isoindole-1,5(6H)-dione 
• 1293305-94-8 tert-butyl (1S,3aR,4S,7aS)-3,6-dioxo-1-phenyl-4-(trimethylsilyl)hexahydro-1H-isoindole-2(3H)-carboxylate 
• 1293305-93-7 (3S,3aS,7S,7aR)-3-phenyl-2-(2-phenylpropan-2-yl)-7-(trimethylsilyl)hexahydro-1H-isoindole-1,5(6H)-dione 

Relevant academic research and scientific papers

A general synthetic approach to the amnesic shellfish toxins: Total synthesis of (-)-isodomoic acid B, (-)-isodomoic acid E and (-)-isodomoic acid F

The alkynylpyrrolidine 4 was made via a dearomatising cyclisation of an aromatic amide, and was elaborated by stannylcupration and palladium-catalysed coupling to achieve the first total synthesis of three members of the isodomoic acid family; the same alkyne can be envisaged as a precursor to several more of this class of amnesic shellfish toxins. The Royal Society of Chemistry.