129332-29-2

Basic information

• Product Name: tert-Butyl (E)-3,5-dihydroxy-7-[3'-(4''-fluorophenyl)-1'-methylethyl-indol-2'-yl]-6-heptenoate
• Synonyms: T-BUTYL(E)-3,5-DIHYDROXY-7-[3'-(4''-FLUOROPHENYL)-1'-METHYLETHYL-INDOL-2'-YL]-6-HEPTENOATE;tert-Butyl (E)-3,5-dihydroxy-7-[3'-(4''-fluorophenyl)-1'-methylethyl-indol-2'-yl]-6-heptenoate;t-Butyl(E)-3,5-dihydroxy-7-[3'-(4''-fluorophenyl)-1'-methylethyl-indol-2'-yl]-6-;tert-Butyl (E)-3,5-d;(R*,S*-(E))-(±)-7-[3- (4-fluorophenyl)-1-(-1-Methylethyl)-1H-indol-2-yl]-3, 5-dihydroxy-6-heptenoic acid 1,1-diMethyl ester;Fluvastatin Related Compound B (15 mg) ([R*,S*-E]-(+/-)-7-[3-(4-fluorophenyl)-1-methylethyl-1H-indol-2-yl]-3,5-dihydroxy-6-heptenoic acid 1,1, dimethylethyl ester);(6E)-7-{3-[1-(4-fluorophenyl)propan-2-yl]-1H-indol-2-yl}-3,5-dihydroxy-8,8-diMethylnon-6-enoate;Fluvastatin sodiuM interMediate F4
• CAS NO: 129332-29-2
• Molecular Formula: C28H34FNO4
• Molecular Weight: 467.57
• Product Categories: Fluvastatine
• Mol File: 129332-29-2.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 642.264 °C at 760 mmHg
• Flash Point: 342.229 °C
• Appearance: /
• Density: 1.139 g/cm³
• Storage Temp.: -20°C Freezer
• Solubility: Chloroform (Slightly), Ethyl Acetate (Slightly)
• PKA: 13.90±0.20(Predicted)
• CAS DataBase Reference: tert-Butyl (E)-3,5-dihydroxy-7-[3'-(4''-fluorophenyl)-1'-methylethyl-indol-2'-yl]-6-heptenoate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-Butyl (E)-3,5-dihydroxy-7-[3'-(4''-fluorophenyl)-1'-methylethyl-indol-2'-yl]-6-heptenoate(129332-29-2)
• EPA Substance Registry System: tert-Butyl (E)-3,5-dihydroxy-7-[3'-(4''-fluorophenyl)-1'-methylethyl-indol-2'-yl]-6-heptenoate(129332-29-2)

Safety Data

• Hazardous Substances Data: 129332-29-2(Hazardous Substances Data)

Usage

Uses

tert-Butyl Fluvastatin (Fluvastatin USP Related Compound B) is a derivative of Fluvastatin (F601250), a synthetic HMG-CoA reductase inhibitor. Antilipemic.

Upstream product

• 375846-25-6 7-[3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-5-hydroxy-3-oxo-6-heptenoic acid-1,1-dimethylethyl ester 
• 93957-50-7 3-<3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl>-2(E)-propenal 
• 1694-31-1 tert-butyl acetoacetate 
• 540-88-5 acetic acid tert-butyl ester 
• 194934-95-7 ((S)-(E))-7-[3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-5-hydroxy-3-oxo-6-heptenoic acid 1,1-dimethylethyl ester 
• 194934-96-8 (E)-(3R,5S)-(+)-7-[3-(4-fluoro-phenyl)-1-isopropyl-1H-indol-2-yl]-3,5-dihydroxy-hept-6-enoic acid 1,1-dimethylethyl ester 
• 194934-97-9 ((R)-(E))-7-[3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-3-hydroxy-5-oxo-6-heptenoic acid 1,1-dimethylethyl ester 
• 194935-00-7 (S-(R*R*)-(E))-7-[3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-3,5-dihydroxy-6-heptenoic acid 1,1-dimethylethyl ester 
• 194935-02-9 ((S)-(E))-7-[3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-3-hydroxy-5-oxo-6-heptenoic acid 1,1-dimethylethyl ester 

Relevant articles and documents

PROCESS FOR THE PREPARATION OF FLUVASTATIN AND SALTS THEREOF

The present invention relates to an improved process for the preparation of fluvastatin or pharmaceutical acceptable salts or derivatives thereof, in particular to a one-pot process for large scale production of Fluvastatin and salts thereof in high yield

A PROCESS FOR THE PREPARATION OF FLUVASTATIN SODIUM

An efficient and economical process for preparing Fluvastatin sodium of the formula (I) with high purity and in high yield is disclosed. Further a process for preparing Fluva keto alcohol of the formula (II b) and cyclic boronate complex of the formula (I

PROCESS FOR THE PREPARATION OF INDOLE DERIVATIVES BY ENZYMATIC ACYLATION

A process for the preparation of compounds of formula (1), by enzymatic acylation to form compounds of formulae (3a) and (3a') and then reacting the compound of formula (3a) with a compound introducing the radical of formula -CH2-COOR8