1293389-13-5Relevant academic research and scientific papers
1-((3S,4S)-4-Amino-1-(4-substituted-1,3,5-triazin-2-yl) pyrrolidin-3-yl)-5,5-difluoropiperidin-2-one inhibitors of DPP-4 for the treatment of type 2 diabetes
Andrews, Kim M.,Beebe, David A.,Benbow, John W.,Boyer, David A.,Doran, Shawn D.,Hui, Yu,Liu, Shenping,McPherson, R. Kirk,Neagu, Constantin,Parker, Janice C.,Piotrowski, David W.,Schneider, Steven R.,Treadway, Judith L.,Vanvolkenberg, Maria A.,Zembrowski, William J.
, p. 1810 - 1814 (2011/05/11)
A 3-amino-4-substituted pyrrolidine series of dipeptidyl peptidase IV (DPP-4) inhibitors was rapidly developed into a candidate series by identification of a polar valerolactam replacement for the lipophilic 2,4,5-trifluorophenyl pharmacophore. The additi
