129340-92-7Relevant academic research and scientific papers
BRIDGED PIPERIDINE DERIVATIVES
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Page/Page column 26, (2012/09/11)
The present invention relates to compounds of formula I hetaryl I, hetaryl II, R1, R2, R3, Y, m, and o or to pharmaceutically active acid addition salts thereof. The present compounds of formula I are modulators for amyloid beta and thus, they may be useful for the treatment or prevention of a disease associated with the deposition of β-amyloid in the brain, in particular Alzheimer's disease, and other diseases such as cerebral amyloid angiopathy, hereditary cerebral hemorrhage with amyloidosis, Dutch-type (HCHWA-D), multi-infarct dementia, dementia pugilistica and Down syndrome.
A study of the synthesis and antiarrhythmic properties of selected 3,7-diheterabicyclo[3.3.1]nonanes with substituents at the 2,4-positions and at the 9-position
Smith,Thompson,Berlin,Holt,Scherlag,Patterson,Lazzara
, p. 1 - 8 (2007/10/02)
Some members of the family of 3,7-diheterabicyclo[3.3.1]nonanes with substituents at the 2-, 4- and 9-positions were synthesized via a Mannich reaction. Hearts of anesthetized dogs with myocardial infarctions were subjected to ventricular tachycardia (VT)
