89398-04-9

Usage

InChI:InChI=1/C14H17NOS/c16-14-12-7-15(8-13(14)10-17-9-12)6-11-4-2-1-3-5-11/h1-5,12-13H,6-10H2

Upstream product

• 1072-72-6 Tetrahydrothiopyran-4-one 
• 50-00-0 formaldehyd 
• 100-46-9 benzylamine 
• 3287-99-8 benzylamine hydrochloride 

Downstream Products

• 118958-19-3 7-benzyl-9,9-dimethoxy-3-thia-7-azabicyclo<3.3.1>nonane hydroperchlorate 
• 129340-92-7 (rac)-7-benzyl-3-thia-7-aza-bicyclo[3.3.1]nonan-9-one oxime 
• 89398-06-1 7-benzyl-3-thia-7-azabicyclo[3.3.1]nonane 
• 251904-93-5 (4-fluoro-phenyl)-(3-thia-7-aza-bicyclo[3.3.1]non-7-yl)-methanone 

Relevant academic research and scientific papers

BRIDGED PIPERIDINE DERIVATIVES

The present invention relates to compounds of formula I hetaryl I, hetaryl II, R1, R2, R3, Y, m, and o or to pharmaceutically active acid addition salts thereof. The present compounds of formula I are modulators for amyloid beta and thus, they may be useful for the treatment or prevention of a disease associated with the deposition of β-amyloid in the brain, in particular Alzheimer's disease, and other diseases such as cerebral amyloid angiopathy, hereditary cerebral hemorrhage with amyloidosis, Dutch-type (HCHWA-D), multi-infarct dementia, dementia pugilistica and Down syndrome.

3,7,9-Triheterabicyclodecan-10-ones: An Unusual Family of Heterocycles Obtained from 3,7-Diheterabicyclononan-9-ones

A series of new 3,7,9-triheterabicyclodecan-10-ones is reported for the first time.Members of the family of 3,7-diheterabicyclononan-9-ones served as precursors of the title compounds.Spectral evidence suggests the 3,7,9-triheterabicyclodecan-10-ones exist in a chair-boat (CB) ->/nonan-9-one precursors in solution may influence the ease of oxygen and nitrogen insertion in the ring enlargement to give the title molecules.Confirmation that three members of the bicyclodecan-10-ones exist in BC forms in the solid state was achieved via single crystal X-ray diffraction analysis for 7-benzyl-3-thia-7,9-diazabicyclodecan-10-one (4a), 3,7-dibenzyl-3,7,9-triazabicyclodecan-10-one (4c), and 3,7-dibenzyl-9-oxa-3,7-diazabicyclodecan-10-one (4d).

Salts of 3-azabicyclo [3.3.1]nonanes as antiarrhythmic agents, and precursors thereof

Salts of 3-azabicyclo[3.3.1]nonanes are used in controlling antiarrhythmic processes and precursors thereof are disclosed.

Salts of 3-azabicyclo[3.3.1]nonanes as antiarrhythmic agents, and precursors thereof

Salts of 3-azabicyclo[3.3.1]nonanes are used in controlling antiarrhythmic processes and precursors thereof are disclosed.

THE MANNICH CONDENSATION WITH 1-HETERA-4-CYCLOHEXANONES. THE NOVEL FORMATION OF 7-BENZYL-3-HETERA-7-AZABICYCLONONAN-9-ONES, 3,6-DIBENZYLHEXAHYDRO-8a-METHOXY 5H-4a,8-(METHANOHETERAMETHANO)-2H-PYRIDO-1,3-OXAZINES, AND 2,4,10,12-TETRABENZYL-2,4,10,12-TETRAAZA-15-HETERADISPI...

We report for the first time the formation of unusual multicyclic products from the condensation of 1-hetera-4-cyclohexanones in a Mannich reaction with benzylamine, formaldehyde, and acetic acid in methanol.In addition to the expected ketones, namely 7-benzyl-3-hetera-7-azabicyclononan-9-ones, there were obtained from 4-thianone and 4-selenanone the following systems.Repeated Mannich condensations produced 3,6-dibenzylhexahydro-8a-(methoxy-5H-4a,8-(methanothiomethano)-2H-pyrido-1,3-oxazine, 3,6-dibenzylhexahydro-8a-methoxy-5H-4a,8-(methanoselenomethano)-2H-pyrido-1,3-oxazine, 2,4,10,12-tetrabenzyl-2,4,10,12-tetraaza-15-thiadispiro-hexadecan-7-one, and 2,4,10,12-tetrabenzyl-2,4,10,12-tetraza-15-selenadispirohexadecan-7-one.Single crystal X-ray diffraction analysis confirmed the structures of the first three solids.Using tetrahydro-4H-pyran-4-one, it was possible to obtain 7-benzyl-3-oxa-7-azabicyclononan-9-one and 2,4,10,12-tetrabenzyl-2,4,10,12-tetraaza-15-oxadispirohexadecan-7-one.To the best of our knowledge, these systems have not been previously recorded, and the method reported herein is a one-step approach.NMR analyses, including 1H, 13C, and 15N analyses, were completed and support all of the structures described herein.A mechanism is briefly outlined to explain the formation of these novel polycyclic heterocycles. - Key words: Mannich reaction; 1-hetera-4-cyclohexanones; 3,6-dibenzylhexahydro-8a-methoxy-5H-4a,8-(methanoheteromethano)-2H-pyrido--1,3-oxazine; 2,4,10,12-tetrabenzyl-2,4,10,12-tetraaza-15-heteradispirohexadecan-7-one; 7-benzyl-3-hetera-7-azabicyclononan-9-ones; selenium and sulfur derivatives.

3-thia-7-azabicyclo(3.3.l)nonanes and derivatives as antiarrhythmic agents

3-Thia-7-azabicyclo(3.3.1)nonanes and derivatives thereof are disclosed. The preparation of these compounds is given. Their use as antiarrhythmic agents is given.

ISOLATION AND SINGLE-CRYSTAL X-RAY DIFFRACTION ANALYSIS OF N-BENZYL-3-THIA-7-AZABICYCLONONAN-9,9-DIOL PERCHLORATE, A NOVEL HYDRATE FORMED FROM REACTION OF N-BENZYL-3-THIA-7-AZABICYCLONONAN-9-ONE WITH PERCHLORIC ACID

We report the isolation and single crystal X-ray diffraction analysis of N-benzyl-3-thia-7-azabicyclononan-9,9-diol perchlorate which is the hydrate obtained from reaction of N-benzyl-3-thia-7-azabyciclononan-9-one with perchloric acid.Synth