1293410-41-9

Basic information

• Product Name: 3-(((E)-[4-(4-chlorophenoxy)phenyl]methylidene)amino)-2-methylquinazolin-4(3H)-one
• Synonyms: 3-(((E)-[4-(4-chlorophenoxy)phenyl]methylidene)amino)-2-methylquinazolin-4(3H)-one
• CAS NO: 1293410-41-9
• Molecular Weight: 389.841
• Mol File: 1293410-41-9.mol

Chemical Properties

• CAS DataBase Reference: 3-(((E)-[4-(4-chlorophenoxy)phenyl]methylidene)amino)-2-methylquinazolin-4(3H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(((E)-[4-(4-chlorophenoxy)phenyl]methylidene)amino)-2-methylquinazolin-4(3H)-one(1293410-41-9)
• EPA Substance Registry System: 3-(((E)-[4-(4-chlorophenoxy)phenyl]methylidene)amino)-2-methylquinazolin-4(3H)-one(1293410-41-9)

Safety Data

• Hazardous Substances Data: 1293410-41-9(Hazardous Substances Data)

Upstream product

• 118-92-3 anthranilic acid 
• 106-48-9 4-chloro-phenol 
• 459-57-4 4-fluorobenzaldehyde 
• 1898-06-2 3-amino-2-methyl-4-oxoquinazoline 
• 61343-99-5 4-(4'-chlorophenoxy)benzaldehyde 
• 525-76-8 2-methyl-4-oxo-3,1-benzoxazine 

Relevant articles and documents

Design, synthesis and potential 6 Hz psychomotor seizure test activity of some novel 2-(substituted)-3-{[substituted]amino}quinazolin-4(3H)-one

Thirty new 2-(substituted)-3-{[substituted]amino}quinazolin-4(3H)-one were designed and synthesized keeping in view the structural requirement of pharmacophore and evaluated for anticonvulsant activity and neurotoxicity. The anticonvulsant activity of the titled compounds was assessed using the 6 Hz psychomotor seizure test. The most active compound of the series was 3-({(E)-[3-(4-chloro-3-methylphenoxy)phenyl]methylidene}amino) -2-phenylquinazolin-4(3H)-one PhQZ 7, which showed 100% protection (4/4, 0.5 h) and 75% protection (3/4, 0.25 h) at a dose of 100 mg/kg in mice. A computational study was carried out for calculation of pharmacophore pattern and prediction of pharmacokinetic properties. Titled compounds have also exhibited good binding properties with epilepsy molecular targets such as glutamate, GABA (A) delta and GABA (A) alpha-1 receptors, in Lamarckian genetic algorithm based flexible docking studies.