129374-60-3

Upstream product

• 94271-66-6 diethyl (+/-)-3-isopropyl-1-(2,4-dimethoxybenzyl)-4-oxo-2,2-azetidinedicarboxylate 
• 129374-57-8 dimethyl 1-(2,4-dimethoxybenzyl)-3-isopropyl-4-oxoazetidine-2,2-dicarboxylate 
• 94271-67-7 1-(2,4-Dimethoxy-benzyl)-3-isopropyl-4-oxo-azetidine-2-carboxylic acid ethyl ester 
• 94271-67-7 ethyl (+/-)-3-isopropyl-1-(2,4-dimethoxybenzyl)-4-oxo-2-azetidinecarboxylate 
• 129374-59-0 (2S,3S)-1-(2,4-Dimethoxy-benzyl)-3-isopropyl-4-oxo-azetidine-2-carboxylic acid methyl ester 

Downstream Products

• 129374-88-5 2-Hydroxy-2-((2S,3S)-3-isopropyl-2-methanesulfonyloxymethyl-4-oxo-azetidin-1-yl)-3-oxo-butyric acid benzyl ester 
• 136582-28-0 cis-benzyl 3-hydroxy-2-<2-oxo-3-isopropyl-4-(methylsulfonyloxymethyl)azetidin-1-yl>but-2-enoate 
• 129374-68-1 cis-benzyl 7-isopropyl-3-methyl-2-isocephem-4-carboxylate 
• 129374-66-9 cis-benzyl 7-isopropyl-3-methyl-2-iso-oxacephem-4-carboxylate 
• 129374-88-5 2-Hydroxy-2-((2S,3R)-3-isopropyl-2-methanesulfonyloxymethyl-4-oxo-azetidin-1-yl)-3-oxo-butyric acid benzyl ester 
• 136582-28-0 trans-benzyl 3-hydroxy-2-<2-oxo-3-isopropyl-4-(methylsulfonyloxymethyl)azetidin-1-yl>but-2-enoate 
• 129374-68-1 trans-benzyl 7-isopropyl-3-methyl-2-isocephem-4-carboxylate 
• 129374-66-9 benzyl (+/-)-trans-7-isopropyl-3-methyl-2-isoxacephem-4-carboxylate 

Relevant academic research and scientific papers

Simple and Condensed &β-Lactams. Part 21. Synthesis of Some Compounds Related to the Monobactams, Carrying non-Acylamino Substituents in Position 3 and Heterocyclic Quaternary Ammoniomethyl Substituents in Position 4 of the &β-Lactam Ring.

The synthesis of racemic azetidinones (13,3,4 cis and trans, where applicable) related to the monobactams is described.None of the new compounds prepared exhibited any significant antibacterial activity.

Simple and Condensed β-Lactams 12. Alternative Entry into the 2-Isocephem and 2-Iso-oxacephem Series.

The N-Unsubstituted-2-azetidinones ( 17a,b) react smoothly with esters of 2,3-dioxobutyric acid.In resulting intermediates (29b; 30a,b) were converted into the acetoacetates (33b; 34a,b) which were cyclized and deprotected to give the 2-iso-oxacephem- and 2-isocephem-4-carboxylic acids (1a,b) and (2a,b).