94271-67-7

Upstream product

• 94271-67-7 1-(2,4-Dimethoxy-benzyl)-3-isopropyl-4-oxo-azetidine-2-carboxylic acid ethyl ester 
• 94271-65-5 diethyl (+/-)-N-(2-bromo-3-methylbutanoyl)-N-(2,4-dimethoxybenzyl)aminomalonate 
• 81902-49-0 diethyl N-(2,4-dimethoxybenzyl)-amino-malonate 
• 27109-47-3 2-bromoisovaleryl chloride 
• 94271-66-6 diethyl (+/-)-3-isopropyl-1-(2,4-dimethoxybenzyl)-4-oxo-2,2-azetidinedicarboxylate 

Downstream Products

• 129374-60-3 (3R,4S)-1-(2,4-Dimethoxy-benzyl)-4-hydroxymethyl-3-isopropyl-azetidin-2-one 
• 94271-67-7 ethyl (+/-)-3-isopropyl-1-(2,4-dimethoxybenzyl)-4-oxo-2-azetidinecarboxylate 
• 129374-88-5 2-Hydroxy-2-((2S,3S)-3-isopropyl-2-methanesulfonyloxymethyl-4-oxo-azetidin-1-yl)-3-oxo-butyric acid benzyl ester 
• 136582-28-0 cis-benzyl 3-hydroxy-2-<2-oxo-3-isopropyl-4-(methylsulfonyloxymethyl)azetidin-1-yl>but-2-enoate 
• 129374-68-1 cis-benzyl 7-isopropyl-3-methyl-2-isocephem-4-carboxylate 
• 129374-66-9 cis-benzyl 7-isopropyl-3-methyl-2-iso-oxacephem-4-carboxylate 
• 129374-60-3 cis-4-hydroxymethyl-3-isopropyl-1-(2,4-dimethoxybenzyl)azetidin-2-one 

Relevant academic research and scientific papers

Simple and Condensed &β-Lactams. Part 21. Synthesis of Some Compounds Related to the Monobactams, Carrying non-Acylamino Substituents in Position 3 and Heterocyclic Quaternary Ammoniomethyl Substituents in Position 4 of the &β-Lactam Ring.

The synthesis of racemic azetidinones (13,3,4 cis and trans, where applicable) related to the monobactams is described.None of the new compounds prepared exhibited any significant antibacterial activity.

Simple and Condensed β-Lactams 12. Alternative Entry into the 2-Isocephem and 2-Iso-oxacephem Series.

The N-Unsubstituted-2-azetidinones ( 17a,b) react smoothly with esters of 2,3-dioxobutyric acid.In resulting intermediates (29b; 30a,b) were converted into the acetoacetates (33b; 34a,b) which were cyclized and deprotected to give the 2-iso-oxacephem- and 2-isocephem-4-carboxylic acids (1a,b) and (2a,b).

SIMPLE AND CONDENSED β-LACTAMS. Part 6. A Synthesis of the p-Nitrobenzyl Esters of the Racemic Forms of the Carbapenem Antibiotics PS-5 and PS-6, and of Their 6-Epimers.

The p-nitrobenzyl esters of the racemic carbapenem antibiotics PS-5 and PS-6, and of their 6-epimers were synthesised starting with the trans (6a, 6c) and cis forms (6b, 6d) of ethyl 1-(2,4-dimethoxybenzyl)-4-oxo-2-azetidinecarboxylates, respectively.