129376-74-5

Upstream product

• 139167-15-0 2-(tert-butylphenylsilyloxy)acetophenone 
• 16355-00-3 (R)-1-phenyl-1,2-ethanediol 
• 58479-61-1 tert-butylchlorodiphenylsilane 

Downstream Products

• 129376-69-8 (R)-1-Phenyl-2-(<(tert-butyl)diphenylsilyl>oxy)ethyl (2'S,3R)-2-Methyl-1'-(4-toluenesulfonyl)spiro<3H-indole-3,3'-pyrrolidine>-2'-carboxylate 
• 129376-69-8 (R)-1-Phenyl-2-(<(tert-butyl)diphenylsilyl>oxy)ethyl (2'R,3S)-2-Methyl-1'-(4-toluenesulfonyl)spiro<3H-indole-3,3'-pyrrolidine>-2'-carboxylate 
• 129395-21-7 (R)-2-(<(tert-Butyl)diphenylsilyl>oxy)-1-phenylethyl Dihydroxyacetate 
• 201158-68-1 Acetic acid (2S,3R,4S,6S)-3-benzyloxycarbonylamino-6-[(R)-2-(tert-butyl-diphenyl-silanyloxy)-1-phenyl-ethoxy]-2-methyl-tetrahydro-pyran-4-yl ester 
• 129376-73-4 (R)-2-(<(tert-Butyl)diphenylsilyl>oxy)-1-phenylethyl Acrylate 

Relevant academic research and scientific papers

Hyperbranched chiral catalysts for the asymmetric reduction of ketones with borane

Optically active dendritic amino alcohols catalyse the enantioselective borane reduction of ketones with good yields and high enantiomeric excesses.

Use of NaBH4/Me3SiCl in the β-hydroxysulfoximine-catalyzed enantioselective reduction of ketones

The use of NaBH4/Me3SiCl in the β-hydroxysulfoximine-catalyzed asymmetric reduction of ketones affords secondary alcohols in high yields with good enantioselectivities (up to 90% ee).

On the chemoselectivity and mechanism of desilylation of tert- butyldimethylsilyl ethers with TMSOTf

A modified literature procedure is presented for desilylating primary and secondary tert-butyldimethylsilyl ethers involving TMSOTf followed by breakdown of the bis-silyloxonium ion in methanol. The chemoselectivity of the process with respect to TBDPS, T

48. Diastereoselective Spirocyclization of C-(Alkyloxycarbonyl)formimines of 2-Substituted 1H-Indole-3-ethanamines (= Tryptamines): Basic Studies

C-(Alkoxycarbonyl)formimines of type 15-18 were derived from the 2-substituted tryptamines 2, 9, 10, and 11 and transformed with tosyl chloride into tricyclic 3-spiroindoles of types 19-22 (Scheme 3).The influence of the homochiral alkoxy moieties A-D on the stereochemical outcome of this reaction was studied.Good-to-excellent diastereoselectivities were observed with the (-)-8-(phenylmenth-3-yl)oxy group (B) as homochiral auxiliary.The structures of the tricycles 4, (2'R,3S)-19B, and (2'S,3R)-20C were established by X-ray analysis, the structures of the others by NOE and CD studies, and by chemical correlation.Possibilities to explain the steric course of the spirocyclizations are discussed.