1293935-96-2Relevant academic research and scientific papers
An straightforward entry to new pyrazolo-fused dibenzo[1,4]diazepines
Hernandez, Susana,Moreno, Isabel,Sanmartin, Raul,Teresa Herrero, Maria,Dominguez, Esther
, p. 2251 - 2257 (2011/04/26)
A series of novel pyrazolodibenzo[1,4]diazepines has been synthesized with good overall yields. The diarylpyrazole intermediates, with structure similarity to biologically relevant compounds such as currently marketed drugs like rimonabant or celecoxib, were prepared by a tandem sequence amine-exchange/ heterocyclization starting from readily available enaminones and arylhydrazines. The key step of this efficient methodology was Caryl-N bond construction, accomplished by a palladium-catalyzed intramolecular N-arylation reaction, which was conducted in both homogeneous and polymer-supported versions. Reaction scope of such protocols and recycling of the heterogeneous catalyst were also examined.
