129394-03-2Relevant academic research and scientific papers
Conformational behaviour of trans-2,3-bis(R-thio)-1,4-dioxanes
Riera,Pericas,Cabre
, p. 2755 - 2758 (2007/10/02)
The conformation of eight trans-2,3-bis(R-thio)-1,4-dioxanes has been studied in chloroform solution using 1H NMR techniques. Among the alkylthio substituted compounds, the population of diaxial conformer increases from methylthio (71%) to tert-butylthio (85%). The arylthio substituted compounds exist largely as diaxial conformers (ca 90%). The alleviation of anomeric effects in trans-2,3-bis(R-oxy)-1,4-dioxanes bearing bulky alkoxy groups is discussed at the light of these results.
