95-59-0

Basic information

• Product Name: 2,3-DICHLORO-P-DIOXANE
• Synonyms: 2,3-Dichloro-1,4-dioxane;2,3-dichloro-4-dioxane;2,5-dichloro-p-dioxane;p-Dioxane, 2,3-dichloro-;2,3-DICHLORO-P-DIOXANE;NISTC95590;2,3-DICHLORO-PARA-DIOXANE
• CAS NO: 95-59-0
• Molecular Formula: C₄H₆Cl₂O₂
• Molecular Weight: 156.99524
• EINECS: 202-435-3
• Mol File: 95-59-0.mol

Chemical Properties

• Melting Point: 30°C
• Boiling Point: 218.43°C (rough estimate)
• Flash Point: 93.9 °C
• Appearance: /
• Density: 1.4680
• Vapor Pressure: 0.209mmHg at 25°C
• Refractive Index: 1.4928 (estimate)
• CAS DataBase Reference: 2,3-DICHLORO-P-DIOXANE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-DICHLORO-P-DIOXANE(95-59-0)
• EPA Substance Registry System: 2,3-DICHLORO-P-DIOXANE(95-59-0)

Safety Data

• Hazardous Substances Data: 95-59-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2,3-DICHLORO-P-DIOXANE is used as a key intermediate in the synthesis of 4-(2-Aminophenyl)-3-morpholinone (A625985), which is a reagent employed in the preparation of various Morpholine-based pharmaceuticals. This makes it an essential component in the development of a wide range of medications that can potentially treat different medical conditions.

InChI:InChI=1/C4H6Cl2O2/c5-3-4(6)8-2-1-7-3/h3-4H,1-2H2

Upstream product

• 95-59-0 trans-2,3-dichloro-1,4-dioxane 
• 56-23-5 tetrachloromethane 
• 543-75-9 1,4-dioxene 
• 7782-50-5 chlorine 
• 123-91-1 1,4-dioxane 
• 7446-70-0 aluminium trichloride 
• 3883-42-9 cis-2,3-dichloro-1,4-dioxane 
• 71-43-2 benzene 
• 7719-09-7 thionyl chloride 

Downstream Products

• 854388-33-3 2,3-bis-(4-nitro-phenoxy)-[1,4]dioxane 
• 131543-46-9 Glyoxal 
• 107-21-1 ethylene glycol 
• 4336-10-1 cis-2,3-diphenyl-[1,4]dioxane 
• 4336-10-1 (+/-)-trans-2,3-diphenyl-[1,4]dioxane 
• 16088-56-5 cis-2,3-bis-diethoxythiophosphorylmercapto-[1,4]dioxane 
• 78-34-2 (+/-)-trans-2,3-bis-diethoxythiophosphorylmercapto-[1,4]dioxane 
• 7504-91-8 2,3-Bis-<4-chlor-phenyl>-1,4-dioxan 
• 138609-88-8 1,1,2,2-tetrakis(benzylthio)etane 
• 35030-10-5 (+/-)-2r,3t-bis-(4-methoxy-phenyl)-[1,4]dioxane 
• 72701-41-8 2,3-diphenoxy-[1,4]dioxane 
• 95-59-0 (-)-2r,3t-dichloro-[1,4]dioxane 
• 101392-91-0 trans-2,3-bis(2,6-dimethylphenoxy)-1,4-dioxane 
• 129394-03-2 (2R,3R)-2,3-Bis-(4-chloro-phenylsulfanyl)-[1,4]dioxane 

Relevant articles and documents

Synthesis of isotopically labeled fusarium mycotoxin 13C 2-moniliformin [1-hydroxycyclobut-1-ene-3,4-dione]

The total synthesis of isotopically labeled [13C-1- hydroxycyclobut-1-ene-3,4-dione (moniliformin) a fungal toxic secondary metabolite to be used as internal standard for mycotoxin analysis is described. The synthesis proceeds in four steps starting from 1,4-dioxane, which was converted to 2,3-dihydro-1,4-dioxine followed by a [2+2]-cycloaddition with trichloroacetyl chloride-1,2-13Cas 13C source. The 13Clabeled cyclobutanone precursor was transformed to [ 13C-moniliformin by acid-catalyzed hydrolysis. The successful incorporation of two 13C atoms was proven by detailed NMR and mass spectrometric studies of labeled moniliformin and its precursor. Georg Thieme Verlag Stuttgart - New York.

Syntheses, structure and conducting properties of halogenated ethylenedioxytetrathiafulvalenes

4,5-Diiodo-, 4,5-dibromo-, and 4,5-dichloro-4′,5′-ethylenedioxytetrathiafulvalenes (EDO-TTFI2, EDO-TTFBr2, and EDO-TTFCl2) were synthesized in moderate to good yields by the two routes. The first route contains the reaction of EDO-TTF with LDA, followed by quenching with halogenated reagents, and the second route consists of the P(OR)3-mediated cross-coupling of 4,5-dihalogenated 1,3-dithiole-2-ones with 4,5-ethylenedioxy-1,3-dithiole-2-thione. The structures of EDO-TTFI2 and EDO-TTFCl2 were determined by X-Ray analysis. The radical-cation salts derived from EDO-TTFI2, EDO-TTFBr2, and EDO-TTFCl2 show high conductivities, although these compounds contain electron-withdrawing halogens as the substituent.

DIISOPROPOXY- AND DI-tert-BUTOXYETHYNE STABLE ACETYLENE DIETHERS

The rather stable acetylene diethers diisopropoxy- and di-t-butoxyethyne are prepared either from glyoxal or dioxane.Catalytic hydrogenation, acid-catalyzed hydration and formation of the corresponding hexacarbonyl dicobalt complexes are reported.