1293966-41-2

Upstream product

• 92973-40-5 methyl (2R,3S)-3,4-O-isopropylidene-2,3,4-trihydroxybutanoate 
• 15042-01-0 5,6-O-isopropylidene-L-ascorbic acid 
• 112031-08-0 Methyl (αR,4S)-2,2-dimethyl-α-methylsulfonyloxy-1,3-dioxolane-4-acetate 
• 1293966-40-1 C₉H₁₅ClO₄ 
• 40217-17-2 (R)-4-(phenylmethyl)-2-oxazolidinone 
• 673-06-3 D-(R)-phenylalanine 
• 5267-64-1 (R)-2-amino-3-phenylpropanol 
• 74134-78-4 (2S,3R)-3,4-epoxy-1,2-O-isopropylidenebutane-1,2-diol 
• 1293966-39-8 C₁₀H₁₇ClO₂ 
• 1268269-17-5 C₁₀H₁₈O₃ 

Downstream Products

• 1293966-80-9 C₅₉H₉₇ClO₁₃Si 
• 1293966-55-8 C₆₅H₁₁₁ClO₁₃Si₂ 
• 1293966-66-1 C₂₀H₂₆ClNO₅ 

Relevant academic research and scientific papers

Synthesis of a diastereomer of the marine macrolide lytophilippine A

The synthesis of a diastereomer of lytophilippine A required 22 longest linear steps using known building blocks. Cross-metathesis/asymmetric aldol addition and regioselective esterification/ring-closing metathesis served as efficient combi tools for scaffold construction. Detailed NMR investigations in different solvent (systems) provide evidence for a deep-seated configurational misassignment of the molecule named lytophilippine A.

Synthetic studies on lytophilippine A: Synthesis of the proposed structure

Chemical equations presented. Synthesis of the proposed structure of lytophilippine A was accomplished employing SmI2-mediated 5-exo cyclization of an aldehydo β-alkoxyvinyl sulfoxide and ring-closing metathesis reaction.