129397-84-8

Upstream product

• 83173-69-7 methyl N^α-(tert-butoxycarbonyl)-N^ω-tosyl-L-argininate 

Downstream Products

• 156774-26-4 (S)-2-{2-[(S)-5-({Amino-[(Z)-toluene-4-sulfonylimino]-methyl}-amino)-2-tert-butoxycarbonylamino-pentylsulfanyl]-benzoylamino}-succinic acid 4-cyclohexyl ester 1-methyl ester 
• 156774-25-3 (S)-2-{2-[(S)-5-({Amino-[(Z)-toluene-4-sulfonylimino]-methyl}-amino)-2-tert-butoxycarbonylamino-pentylsulfanyl]-acetylamino}-succinic acid 4-cyclohexyl ester 1-methyl ester 
• 156774-21-9 2-[(S)-5-({Amino-[(Z)-toluene-4-sulfonylimino]-methyl}-amino)-2-tert-butoxycarbonylamino-pentylsulfanyl]-benzoic acid methyl ester 
• 156774-23-1 2-[(S)-5-({Amino-[(Z)-toluene-4-sulfonylimino]-methyl}-amino)-2-tert-butoxycarbonylamino-pentylsulfanyl]-benzoic acid 
• 156774-20-8 [(S)-5-({Amino-[(Z)-toluene-4-sulfonylimino]-methyl}-amino)-2-tert-butoxycarbonylamino-pentylsulfanyl]-acetic acid methyl ester 
• 156774-22-0 [(S)-5-({Amino-[(Z)-toluene-4-sulfonylimino]-methyl}-amino)-2-tert-butoxycarbonylamino-pentylsulfanyl]-acetic acid 
• 156774-19-5 Toluene-4-sulfonic acid (S)-5-({amino-[(Z)-toluene-4-sulfonylimino]-methyl}-amino)-2-tert-butoxycarbonylamino-pentyl ester 

Relevant academic research and scientific papers

Arg-Gly thiomethylene dipeptide surrogates: Synthesis and incorporation into Arg-Gly-Asp pseudotripeptides

A synthesis of Arg-Gly thiomethylene dipeptide surrogates and the incorporation of these surrogates into Arg-Gly-Asp type pseudotripeptides are described. These compounds are potentially useful for the preparation of small nonpeptide Arg-Gly-Asp peptidomimetics and may find general utility in the fields of peptide chemistry and protein engineering.

PREPARATION OF N-PROTECTED α-AMINO ALCOHOLS BY ACETOXYBOROHYDRIDE REDUCTION OF N-PROTECTED α-AMINO ACID ESTERS

N-Protected α-amino alcohols were prepared by reduction of N-protected α-amino acid esters by sodium acetoxyborohydride in dioxane at elevated temperature.The reductions proceed with excellent yields and without racemisation.Reduction of the carbamate protecting groups was not observed.