Arg-Gly thiomethylene dipeptide surrogates: Synthesis and incorporation into Arg-Gly-Asp pseudotripeptides

Article abstract of DOI:10.1016/S0040-4039(00)76226-5

A synthesis of Arg-Gly thiomethylene dipeptide surrogates and the incorporation of these surrogates into Arg-Gly-Asp type pseudotripeptides are described. These compounds are potentially useful for the preparation of small nonpeptide Arg-Gly-Asp peptidomimetics and may find general utility in the fields of peptide chemistry and protein engineering.