129398-92-1Relevant academic research and scientific papers
Synthesis of a novel nucleic acid mimic: P-boranomethylphosphonate
Lin,Shaw
, p. 1325 - 1328 (2001)
A new type of non-ionic nucleotide analogue with a doubly modified internucleotide linkage, P-boranomethylphosphonate, has been successfully synthesized and characterized. Dithymidine boranomethylphosphonate 5 is the first example of a P-boranomethylphosphonate compound; it is a highly lipophilic phosphodiester analog, which is almost totally resistant to both snake venom phosphodiesterase (SVPDE) and bovine spleen phosphodiesterase (BSPDE). P-boranomethylphosphonates are expected to be promising candidates for mechanistic, diagnostic and therapeutic applications.
A new DMAP-catalyzed phosphonamidite coupling reaction for synthesis of oligonucleotide methylphosphonate derivatives
Lebedev, Alexander V.,Wenzinger, George R.,Wickstrom, Eric
, p. 851 - 854 (2007/10/02)
4-N,N-dimethylaminopyridine (DMAP) catalyzed coupling of 5′-dimethoxy-tritylthymidyl-3′-methylphosphonoamidite and 5′-trifluoroacetyl-3′-acetylthymidine and subsequent oxidation produce dinucleoside methyl phosphonate in a new, less water sensitive coupling reaction.
