129444-75-3

Upstream product

• 75-24-1 trimethylaluminum 
• 78513-07-2 (-)-(2S,3R)-2,3-epoxy-4-(benzyloxy)-1-butanol 
• 77-76-9 2,2-dimethoxy-propane 
• 15681-48-8 lithium dimethylcuprate 

Downstream Products

• 129394-57-6 2-{(2E,4E)-(1S,6S,7S)-1-[(S)-2-(tert-Butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-7-methoxy-4,6-dimethyl-8-phenyl-octa-2,4-dienyl}-isoindole-1,3-dione 
• 129394-57-6 2-{(2E,4E)-(1S,6S,7S)-1-[(S)-2-(tert-Butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-7-methoxy-4,6-dimethyl-8-phenyl-octa-2,4-dienyl}-isoindole-1,3-dione 
• 129371-94-4 2-[(1R,2S)-1-Benzyloxymethyl-3-(tert-butyl-diphenyl-silanyloxy)-2-methyl-propyl]-isoindole-1,3-dione 
• 129371-97-7 (4E,6E)-(2S,3S,8S,9S)-3-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-9-methoxy-2,6,8-trimethyl-10-phenyl-deca-4,6-dienoic acid methyl ester 
• 129371-95-5 (2R,3S)-4-(tert-Butyl-diphenyl-silanyloxy)-2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-3-methyl-butyraldehyde 
• 107441-62-3 (2R,3S)-4-(benzyloxy)-2-methylbutane-1,3-diol 

Relevant academic research and scientific papers

Total synthesis of N-phthaloyl adda methyl ester: All stereocenters originating from a single chiral epoxyalcohol

Selective ring opening of (2S,3R)-epoxide of 4-benzyloxy-cis-2-buten-1-ol either at 2- or 3-position ensures stereospecific construction of all the chiral centers of Adda.