107441-62-3

Upstream product

• 75-24-1 trimethylaluminum 
• 78513-07-2 (-)-(2S,3R)-2,3-epoxy-4-(benzyloxy)-1-butanol 
• 15681-48-8 lithium dimethylcuprate 
• 60656-87-3 benzyloxyacetoaldehyde 
• 87172-27-8 cis-4-benzyloxy-2,3-epoxy-1-butanol 
• 1184-53-8 methylcopper 
• 479483-96-0 (2S,3S)-4-Benzyloxy-3-hydroxy-2-methyl-butyric acid (S)-3-methyl-2-(toluene-4-sulfonylamino)-butyl ester 
• 336182-89-9 (2S,3S)-4-Benzyloxy-3-hydroxy-2-methyl-butyric acid (S)-3-phenyl-2-(toluene-4-sulfonylamino)-propyl ester 
• 129444-75-3 (4S,5R)-4-Benzyloxymethyl-2,2,5-trimethyl-[1,3]dioxane 

Downstream Products

• 129394-57-6 2-{(2E,4E)-(1S,6S,7S)-1-[(S)-2-(tert-Butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-7-methoxy-4,6-dimethyl-8-phenyl-octa-2,4-dienyl}-isoindole-1,3-dione 
• 129394-57-6 2-{(2E,4E)-(1S,6S,7S)-1-[(S)-2-(tert-Butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-7-methoxy-4,6-dimethyl-8-phenyl-octa-2,4-dienyl}-isoindole-1,3-dione 
• 129371-94-4 2-[(1R,2S)-1-Benzyloxymethyl-3-(tert-butyl-diphenyl-silanyloxy)-2-methyl-propyl]-isoindole-1,3-dione 
• 129371-97-7 (4E,6E)-(2S,3S,8S,9S)-3-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-9-methoxy-2,6,8-trimethyl-10-phenyl-deca-4,6-dienoic acid methyl ester 
• 129371-95-5 (2R,3S)-4-(tert-Butyl-diphenyl-silanyloxy)-2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-3-methyl-butyraldehyde 
• 107441-63-4 1-O-benzyl-3-deoxy-3-methyl-D-threitol dipivaloate 
• 107441-72-5 (6ξ,8ξ)-6,9-anhydro-1,3-O-benzylidene-8-<(benzyloxy)methyl>-2,5,8,10-tetradeoxy-2-C-methyl-D-glycero-D-threo-4,7-decodiulose 
• 107441-71-4 (4ξ,6ξ,7ξ,8ξ)-6,9-anhydro-1,3-O-benzylidene-8-<(benzyloxy)methyl>-2,5,8,10-tetradeoxy-2-methyl-6-C-methyl-D-glycero-D-threo-decitol 
• 107441-73-6 (6ξ,8ξ)-6,9-anhydro-8-<(benzyloxy)methyl>-2,5,8,10-tetradeoxy-2-methyl-6-C-methyl-D-glycero-D-threo-4,7-decodiulo-1,4-furano-3,7-pyranose 

Relevant academic research and scientific papers

Studies directed towards the synthesis of immunosuppressive agent FK 506: Synthesis of C-20 to C-27 moiety

Regioselective ring opening of (2S,3R)-epoxide of 4-benzyloxy-cis-2-buten-1-ol with Me2CuLi and diastereofacial selective aldol reaction with enolsilane are the key steps involved in the stereospecific construction of '2-methyl-1,3-diol' backbo

Protecting-group-free diastereoselective C-C coupling of 1,3-glycols and allyl acetate through site-selective primary alcohol dehydrogenation

Safe from protection! A pronounced kinetic preference for primary alcohol dehydrogenation enables the site-selective iridium catalyzed C-C coupling of polyols with allyl acetate in the absence of protecting groups, premetallated reagents, chiral auxiliaries, and discrete alcohol-to-aldehyde oxidation.

Chelation-controlled ester-derived titanium enolate aldol reaction: Diastereoselective syn-aldols with mono- and bidentate aldehydes

A chelation-controlled and highly diastereoselective synthesis of syn-aldols is described. Aldol reaction of (S)-valinol-derived ester with a variety of aldehydes proceeded with high syn-diastereoselectivities (up to 99:1) and isolated yields (94%).

Regioselective Alkyl and Alkynyl Substitution Reactions of Epoxy Alcohols by the Use of Organoaluminum Ate Complexes: Regiochemical Reversal of Nucleophilic Substitution Reactions

(matrix presented) Unprecedented nucleophilic substitution reactions of 2,3-epoxy-1-alkanols with alkyl- and alkynylaluminum ate complexes have been studied and demonstrated to occur at the C2 position with extremely high stereoselectivity, i.e., with exa

Ester derived titanium enolate aldol reaction: Chelation controlled diastereoselective synthesis of syn-aldols

A chelation controlled and highly diastereoselective synthesis of syn-aldols is described. Aldol reaction of commercially available L-phenylalaninol derived esters with a variety of bidentate oxyaldehydes proceeded with excellent syn-diastereoselectivities and isolated yields.

Isomer Selectivity in Stereocontrolled Payne Rearrangement-epoxide Cleavage of 2,3-Epoxy Alcohols in Aprotic Solvents: Application to an Enantioselective Total Synthesis of (+)-exo-Brevicomin

Organo-copper and -cuprate reagents may be used to trap the more reactive epoxy alkoxide isomer in a Lewis acid-catalysed Payne rearrangement process.This methodology has been used as the key step in a five-step enantioselective total synthesis of (+)-exo

Total synthesis of N-phthaloyl adda methyl ester: All stereocenters originating from a single chiral epoxyalcohol

Selective ring opening of (2S,3R)-epoxide of 4-benzyloxy-cis-2-buten-1-ol either at 2- or 3-position ensures stereospecific construction of all the chiral centers of Adda.