1294479-60-9Relevant academic research and scientific papers
COVALENT RAS INHIBITORS AND USES THEREOF
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, (2021/06/04)
The disclosure features compounds, or pharmaceutically acceptable salts thereof, alone and in combination with other therapeutic agents, pharmaceutical compositions, and protein conjugates thereof, capable of modulating biological processes including Ras, and their uses in the treatment of cancers.
RAS INHIBITORS
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, (2021/05/07)
The disclosure features macrocyclic compounds, and pharmaceutical compositions and protein complexes thereof, capable of inhibiting Ras proteins, and their uses in the treatment of cancers.
Highly enantioselective synthesis of anti aryl β-hydroxy α-amino esters via DKR transfer hydrogenation
Liu, Zhuqing,Shultz, C.Scott,Sherwood, Candice A.,Krska, Shane,Dormer, Peter G.,Desmond, Richard,Lee, Claire,Sherer, Edward C.,Shpungin, Joseph,Cuff, James,Xu, Feng
, p. 1685 - 1688 (2011/05/05)
An efficient preparation of highly enantiomerically enriched aryl β-hydroxy α-amino esters via dynamic kinetic resolution (DKR), asymmetric transfer hydrogenation of α-amino β-keto esters is described. The anti β-hydroxyl α-amino esters were obtained both in high yields and high diasteroselectivity. The observed high anti selectivity is inconsistent with the previous results in literature. The absolute stereochemistry of the aryl β-hydroxy α-amino esters was unambiguously confirmed via chemical derivatization as well as Vibrational Circular Dichroism (VCD) techniques.
Stereoselectivity of an ω-transaminase-mediated amination of 1,3-dihydroxy-1-phenylpropane-2-one
Smithies, Kirsty,Smith, Mark E.B.,Kaulmann, Ursula,Galman, James L.,Ward, John M.,Hailes, Helen C.
experimental part, p. 570 - 574 (2009/09/05)
The stereoselectivity of a recently isolated ω-transaminase from Chromobacterium violaceum in the amination of 1,3-dihydroxy-1-phenylpropan-2-one has been determined. The enzyme is not enantioselective towards a racemic mixture of 1,3-dihydroxy-1-phenylpr
