1294479-61-0

Basic information

• Product Name: ethyl (2R,3R)-2-azido-3-hydroxy-3-phenylpropanoate
• Synonyms: ethyl (2R,3R)-2-azido-3-hydroxy-3-phenylpropanoate
• CAS NO: 1294479-61-0
• Molecular Weight: 235.243
• Mol File: 1294479-61-0.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: ethyl (2R,3R)-2-azido-3-hydroxy-3-phenylpropanoate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl (2R,3R)-2-azido-3-hydroxy-3-phenylpropanoate(1294479-61-0)
• EPA Substance Registry System: ethyl (2R,3R)-2-azido-3-hydroxy-3-phenylpropanoate(1294479-61-0)

Safety Data

• Hazardous Substances Data: 1294479-61-0(Hazardous Substances Data)

Upstream product

• 103-36-6 ethyl 3-phenyl-2-propenoate 
• 1294479-60-9 ethyl (2S,3R)-3-hydroxy-2-(((4-nitrophenyl)sulfonyl)oxy)-3-phenylpropanoate 
• 4192-77-2 ethyl cinnamate 
• 108741-12-4 ethyl (2S,3R)-2,3-dihydroxy-3-phenylpropanoate 

Downstream Products

• 105452-39-9 (1R,2S)-(+)-2-amino-1-phenyl-1,3-propanediol 
• 183075-33-4 tert-butyl (1,3-dihydroxy-1-phenylpropan-2-yl)carbamate 

Relevant articles and documents

COVALENT RAS INHIBITORS AND USES THEREOF

The disclosure features compounds, or pharmaceutically acceptable salts thereof, alone and in combination with other therapeutic agents, pharmaceutical compositions, and protein conjugates thereof, capable of modulating biological processes including Ras, and their uses in the treatment of cancers.

Highly enantioselective synthesis of anti aryl β-hydroxy α-amino esters via DKR transfer hydrogenation

An efficient preparation of highly enantiomerically enriched aryl β-hydroxy α-amino esters via dynamic kinetic resolution (DKR), asymmetric transfer hydrogenation of α-amino β-keto esters is described. The anti β-hydroxyl α-amino esters were obtained both in high yields and high diasteroselectivity. The observed high anti selectivity is inconsistent with the previous results in literature. The absolute stereochemistry of the aryl β-hydroxy α-amino esters was unambiguously confirmed via chemical derivatization as well as Vibrational Circular Dichroism (VCD) techniques.