1294481-82-5

Basic information

• Product Name: 9-[(2R)-3,5-bis-O-(4-Chlorobenzoyl)-2-deoxy-2-fluoro-2-Methyl-b-D-erythro-pentofuranosyl]-6-chloro-9H-purin-2-aMine
• Synonyms: 9-[(2R)-3,5-bis-O-(4-Chlorobenzoyl)-2-deoxy-2-fluoro-2-Methyl-b-D-erythro-pentofuranosyl]-6-chloro-9H-purin-2-aMine;9-[(2R)-3,5-Bis-O-(4-chlorobenzoyl)-2-deoxy-2-fluoro-2-methyl-beta-D-erythro-pentofuranosyl]-6-chloro-9H-purin-2-amine;(2R,3R,4R,5R)-5-(2-Amino-6-chloro-9H-purin-9-yl)-2-[(4-chlorobenzoyloxy)methyl]-4-fluoro-4-methyloxolan-3-yl 4-chlorobenzoate;(2R,3R,4R,5R)-5-(2-Amino-6-chloro-9H-purin-9-yl)-2-(((4-chlorobenzoyl)oxy)methyl)-4-fluoro-4-methyltetrahydrofuran-3-yl 4-chlorobenzoate
• CAS NO: 1294481-82-5
• Molecular Formula: C₂₅H₁₉Cl₃FN₅O₅
• Molecular Weight: 594.8062632
• Mol File: 1294481-82-5.mol
• Article Data: 2

Chemical Properties

• Melting Point: 171-176℃
• Boiling Point: 759.4±70.0 °C(Predicted)
• Appearance: /
• Density: 1.63
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 1.69±0.10(Predicted)
• CAS DataBase Reference: 9-[(2R)-3,5-bis-O-(4-Chlorobenzoyl)-2-deoxy-2-fluoro-2-Methyl-b-D-erythro-pentofuranosyl]-6-chloro-9H-purin-2-aMine(CAS DataBase Reference)
• NIST Chemistry Reference: 9-[(2R)-3,5-bis-O-(4-Chlorobenzoyl)-2-deoxy-2-fluoro-2-Methyl-b-D-erythro-pentofuranosyl]-6-chloro-9H-purin-2-aMine(1294481-82-5)
• EPA Substance Registry System: 9-[(2R)-3,5-bis-O-(4-Chlorobenzoyl)-2-deoxy-2-fluoro-2-Methyl-b-D-erythro-pentofuranosyl]-6-chloro-9H-purin-2-aMine(1294481-82-5)

Safety Data

• Hazardous Substances Data: 1294481-82-5(Hazardous Substances Data)

Usage

General Description

The chemical 9-[(2R)-3,5-bis-O-(4-Chlorobenzoyl)-2-deoxy-2-fluoro-2-Methyl-b-D-erythro-pentofuranosyl]-6-chloro-9H-purin-2-aMine is a synthetic nucleoside analog with potential antiviral and antitumor activities. It is a modified form of the natural nucleoside adenosine, with the sugar and base moieties modified to increase its stability and enhance its activity. 9-[(2R)-3,5-bis-O-(4-Chlorobenzoyl)-2-deoxy-2-fluoro-2-Methyl-b-D-erythro-pentofuranosyl]-6-chloro-9H-purin-2-aMine has been studied for its potential use in treating various viral infections and cancer, as it can interfere with the replication of viruses and inhibit the growth of tumor cells. Additionally, its modified structure may make it less susceptible to degradation by enzymes, potentially improving its bioavailability and therapeutic effectiveness. Further research is needed to fully understand its potential uses and mechanisms of action.

Upstream product

• 1199809-22-7 ((2R,3R,4R,5R)-3-(benzoyloxy)-4-fluoro-5-hydroxy-4-methyltetrahydrofuran-2-yl)methyl benzoate 
• 10310-21-1 2-amino-6-chloropurine 
• 874638-80-9 ((2R,3R,4R)-3-benzoyloxy-4-fluoro-4-methyl-5-oxo-tetrahydrofuran-2-yl)methyl benzoate 
• 1294481-81-4 (2R,3R,4R,5R)-5-bromo-2-(((4-chlorobenzoyl)oxy)methyl)-4-fluoro-4-methyltetrahydrofuran-3-yl 4-chlorobenzoate 
• 10310-21-1 2-Amino-6-chloropurin 
• 1294481-80-3 ((2R,3R,4R,5R)-3-((4-chlorobenzoyl)oxy)-4-fluoro-5-hydroxy-4-methyltetrahydrofuran-2-yl)methyl 4-chlorobenzoate 
• 1294481-79-0 ((2R,3R,4R) 3-(4-chlorobenzoyloxy)-4-fluoro-4-methyl-5-oxotetrahydrofuran-2-yl)methyl-4-chlorobenzoate 

Downstream Products

• 1199809-77-2 6-ethoxy-9-((2S,4aR,6R,7R,7aR)-7-fluoro-2-isopropoxy-7-methyl-2-oxo-tetrahydro-2λ(5)-furo[3,2-d][1,3,2]dioxaphosphinin-6-yl)-9H-purin-2-ylamine 
• 1199809-32-9 PSI-938 
• 1199809-27-2 (2R,3R,4R,5R)-5-(2-amino-6-methoxy-9H-purin-9-yl)-4-fluoro-2-(hydroxymethyl)-4-methyltetrahydrofuran-3-ol 
• 1199809-30-7 (2R,3R,4R,5R)-5-(2-amino-6-ethoxy-9H-purin-9-yl)-4-fluoro-2-(hydroxymethyl)-4-methyltetrahydrofuran-3-ol 

Relevant articles and documents

The synthesis of hydroxyaminopurine nucleosied (by machine translation)

A compound or salt thereof having the following structure useful for the treatment of hepatitis C virus (HCV): wherein R 7 is C 1-6 alkyl or C 3-6 cycloalkyl and R 8 is -O(C 1-6 alkyl) or -O(C 3-6 cycloalkyl).