129452-23-9

Upstream product

• 2749-59-9 1,3-dimethyl-5-pyrazolone 
• 108-98-5 thiophenol 
• 27006-76-4 5-chloro-4-formyl-1,3-dimethylpyrazole 

Relevant academic research and scientific papers

Identification of antitumor activity of pyrazole oxime ethers

A series of pyrazole oxime ether derivatives were prepared and examined as cytotoxic agents. In particular, 5-phenoxypyrazole was comparable to doxorubicin, while exhibiting very potent cytotoxicity against XF 498 and HCT15.

Introduction of N-containing heterocycles into pyrazole by nucleophilic aromatic substitution

The nucleophilic aromatic substitution on 5-chloropyrazoles activated by the electron-withdrawing formyl group offers a useful method to introduce a wide range of N-containing heterocycles into them. The rate of reaction was greatly affected by the electronic nature of the N-1 substitution.