129476-64-8

Basic information

• Product Name: 2,2,2-TRIFLUORO-N-PYRAZIN-2-YLACETAMIDE
• Synonyms: 2,2,2-TRIFLUORO-N-PYRAZIN-2-YLACETAMIDE;Acetamide, 2,2,2-trifluoro-N-2-pyrazinyl-;2,2,2-Trifluoro-N-2-pyrazinylacetaMide
• CAS NO: 129476-64-8
• Molecular Formula: C₆H₄F₃N₃O
• Molecular Weight: 191.1107
• Mol File: 129476-64-8.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 269.9°Cat760mmHg
• Flash Point: 117°C
• Appearance: /
• Density: 1.524g/cm³
• Vapor Pressure: 0.00706mmHg at 25°C
• Refractive Index: 1.504
• CAS DataBase Reference: 2,2,2-TRIFLUORO-N-PYRAZIN-2-YLACETAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2,2-TRIFLUORO-N-PYRAZIN-2-YLACETAMIDE(129476-64-8)
• EPA Substance Registry System: 2,2,2-TRIFLUORO-N-PYRAZIN-2-YLACETAMIDE(129476-64-8)

Safety Data

• Hazardous Substances Data: 129476-64-8(Hazardous Substances Data)

Usage

Use

Building block in the synthesis of various medications in the pharmaceutical industry

Derivative

Pyrazine

Functional group

Trifluoromethyl group attached to the nitrogen atom

Physical form

White crystalline solid

Solubility

Insoluble in water, soluble in organic solvents

Stability

High stability

Use as reagent

Often used in chemical reactions to introduce the pyrazinylacetamide motif into organic molecules.

InChI:InChI=1/C6H4F3N3O/c7-6(8,9)5(13)12-4-3-10-1-2-11-4/h1-3H,(H,11,12,13)

Upstream product

• 5049-61-6 2-Aminopyrazine 
• 407-25-0 trifluoroacetic anhydride 
• 383-63-1 ethyl trifluoroacetate, 

Downstream Products

• 1575608-05-7 (2R,3R)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-3-(2-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[1,5-a]piperazine-7(8H)-yl)butan-2-ol 
• 681249-57-0 2-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyrazine 
• 681249-55-8 2,2,2-trifluoro-N’-hydroxy-N-pyrazin-2-ylacetimidamide 

Relevant articles and documents

Synthesis process of PARP inhibitor fluzopanb intermediate

The invention discloses a process method suitable for large-scale preparation of 2-trifluoromethyl [1,2,4]triazolo[1,5-a] pyrazine, and belongs to the field of drug intermediate synthesis, wherein 2-aminopyrazine and ethyl trifluoroacetate are used as raw materials, and a transesterification reaction, a substitution reaction and a dehydration reaction are performed to obtain 2-trifluoromethyl [1,2,4]triazolo[1,5-a] pyrazine. According to the process disclosed by the invention, cheap ethyl trifluoroacetate is selected to replace expensive trifluoroacetic anhydride, other organic solvents replace a first-class solvent dichloroethane, and TFFA replaces PPA which is difficult to post-treat, so that the production cost of existing biological, medical and chemical intermediates is greatly reduced, amplification verification is conducted on the kilogram-level scale of the process, the yield and the product purity are basically equivalent to those of the gram-level scale, and the process is expected to serve as an industrial large-scale production process.

The ortho and meta magnesiation of functionalized anilines and amino-substituted pyridines and pyrazines at room temperature

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AMINOTETRAHYDROPYRANS AS DIPEPTIDYL PEPTIDASE-IV INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES

The present invention is directed to novel substituted aminotetrahydropyrans of structural formula I which are inhibitors of the dipeptidyl peptidase-IV enzyme and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.