129477-21-0

Basic information

• Product Name: 5-BROMO-2-METHYL-NICOTINIC ACID ETHYL ESTER
• Synonyms: 5-BROMO-2-METHYL-NICOTINIC ACID ETHYL ESTER;5-Bromo-2-methylnicotinic acid ethyl ester ,98%;Ethyl 5-broMo-2-Methylnicotinate;5-Bromo-2-methyl-3-pyridinecarboxylic acid ethyl ester;5-BroMo-2-Methylnicotinic acid ethyl esther;ethyl 5-broMo-2-Methylpyridine-3-carboxylate;3-Pyridinecarboxylic acid, 5-broMo-2-Methyl-, ethyl ester
• CAS NO: 129477-21-0
• Molecular Formula: C9H10BrNO2
• Molecular Weight: 244.09
• Mol File: 129477-21-0.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 263℃
• Flash Point: 113℃
• Appearance: Pale yellow/Solid
• Density: 1.439
• Vapor Pressure: 0.011mmHg at 25°C
• Refractive Index: 1.541
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 1.66±0.20(Predicted)
• Water Solubility: Slightly soluble in water.
• CAS DataBase Reference: 5-BROMO-2-METHYL-NICOTINIC ACID ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 5-BROMO-2-METHYL-NICOTINIC ACID ETHYL ESTER(129477-21-0)
• EPA Substance Registry System: 5-BROMO-2-METHYL-NICOTINIC ACID ETHYL ESTER(129477-21-0)

Safety Data

• Safety Statements: 24/25
• Hazardous Substances Data: 129477-21-0(Hazardous Substances Data)

Usage

Uses

Ethyl 5-bromo-2-methylnicotinate is used as a pharmaceutical intermediate.

InChI:InChI=1/C9H10BrNO2/c1-3-13-9(12)8-4-7(10)5-11-6(8)2/h4-5H,3H2,1-2H3

Upstream product

• 291756-78-0 N-(2-bromo-3-(dimethylamino)allylidene)-N-methylmethanaminium hexafluorophosphate 
• 141-97-9 ethyl acetoacetate 
• 14925-39-4 2-bromoacrolein 
• 609-15-4 ethyl 2-chloro-3-oxo-butyrate 
• 60390-42-3 ethyl 5-amino-2-methylnicotinate 

Downstream Products

• 1150561-58-2 ethyl 2-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)nicotinate 
• 1260665-60-8 3-bromo-7,8-dihydro-l,6-naphthyridin-5(6H)-one 
• 1173699-31-4 AMG 337 
• 1346539-82-9 ethyl 5-bromo-2-(difluoromethyl)nicotinate 
• 1393553-06-4 3-methoxy-1,6-naphthyridin-5(6H)-one 

Relevant articles and documents

A 5 - bromo -2 - methyl nicotinic acid ethyl ester

The invention discloses a 5 - bromo - 2 - methyl nicotinic acid ethyl ester synthetic method, comprises the following steps: the acetyl ethyl acetate and alkali A adding solvent in the B enolizable; adding intermediate III and DABCO reaction; adding ammonium to cyclization; adding water quenching, organic solvent extraction C; removing the organic solvent to be crystalline crude product shall C; to be crystalline crude product recrystallized from 5 - bromo - 2 - methyl nicotinic acid ethyl ester; the invention to Meck development of 5 - chloro - 2 - methyl nicotinic acid ethyl ester is based on, through changing the reaction solvent and reduce the reaction temperature, significantly improves the stability of the intermediate III, so that the reaction can be smoothly to obtain the product, after treatment through recrystallization purification, thus avoiding the time-consuming column chromatography process, the average yield of 70%, the purity of 99.0% or more, is suitable for the large-scale industrial production.

NITROGEN-CONTAINING HETEROCYCLIC COMPOUNDS AND BENAMIDE COMPOUNDS AND DRUGS CONTAINING THE SAME

Disclosed are compounds represented by formula (I) which have triglyceride biosynthesis inhibitory activity in the liver and inhibitory activity against the secretion of apolipoprotein B-containing lipoprotein from the liver and particularly have excellent inhibitory activity against the secretion of apolipoprotein B-containing lipoprotein, are free from side effect of accumulation of lipids in the liver, and are useful for the treatment and prevention of hyperlipidemia and arteriosclerotic diseases. In formula (I), R1 and R2 represent alkyl, alkoxy, cycloalkyl, phenyl, alkenyl, alkynyl, or a five- or six-membered saturated or unsaturated heterocyclic ring, or R1 and R2, together with a nitrogen atom to which R1 and R2 are attached, may form a ring; R3 and R4 represent a hydrogen atom, alkyl, a halogen atom, hydroxyl, nitrile, alkoxycarbonyl, alkoxy, or carboxyl; or R2 and R3 may be attached to each other to form -(CH2)m-, -N=CH-, -CH=N-, or -(C1-6 alkyl)C=N-; A, D, E, and G each represent a carbon atom, or any one of A, D, E, and G represents a nitrogen atom with the other three each representing a carbon atom; Q represents a nitrogen atom or a carbon atom; Y represents a group represented by formula (II) wherein X represents a hydrogen atom, group -C(=O)N(R5)R6 or group -C(=O)OR7, R8 is absent or represents a bond, an oxygen atom, a sulfur atom, -SO2-, -SO-, -CH2-CH2-, or - CH=CH-, and R9 and R10 represent a hydrogen atom, alkyl, alkoxy, a halogen atom, or hydroxyl; and Z represents - (CH2)n-, -O-(CH2)i-, or -C(=O)NH-(CH2)i-.