1393553-06-4 Usage
General Description
3-methoxy-1,6-naphthyridin-5(6H)-one is a chemical compound with the molecular formula C11H9NO2. It is a derivative of naphthyridine, a heterocyclic compound often used in the pharmaceutical industry. 3-methoxy-1,6-naphthyridin-5(6H)-one has a methoxy group (CH3O-) attached to the 3-position of the naphthyridine ring, and a carbonyl group at the 5-position, which gives it its ketone functionality. It is used in the synthesis of various bioactive compounds and pharmaceuticals due to its unique structure and potential medicinal properties. Studies have shown that 3-methoxy-1,6-naphthyridin-5(6H)-one displays antifungal and antibacterial activities, making it a potential candidate for the development of new drugs to combat infectious diseases.
Check Digit Verification of cas no
The CAS Registry Mumber 1393553-06-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,9,3,5,5 and 3 respectively; the second part has 2 digits, 0 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1393553-06:
(9*1)+(8*3)+(7*9)+(6*3)+(5*5)+(4*5)+(3*3)+(2*0)+(1*6)=174
174 % 10 = 4
So 1393553-06-4 is a valid CAS Registry Number.
1393553-06-4Relevant articles and documents
Discovery of (R)-6-(1-(8-Fluoro-6-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4,3-a]pyridin-3-yl)ethyl)-3-(2-methoxyethoxy)-1,6-naphthyridin-5(6H)-one (AMG 337), a Potent and Selective Inhibitor of MET with High Unbound Target Coverage and Robust in Vivo Antitumor Activity
Boezio, Alessandro A.,Copeland, Katrina W.,Rex, Karen,K Albrecht, Brian,Bauer, David,Bellon, Steven F.,Boezio, Christiane,Broome, Martin A.,Choquette, Deborah,Coxon, Angela,Dussault, Isabelle,Hirai, Satoko,Lewis, Richard,Lin, Min-Hwa Jasmine,Lohman, Julia,Liu, Jingzhou,Peterson, Emily A.,Potashman, Michele,Shimanovich, Roman,Teffera, Yohannes,Whittington, Douglas A.,Vaida, Karina R.,Harmange, Jean-Christophe
, p. 2328 - 2342 (2016)
Deregulation of the receptor tyrosine kinase mesenchymal epithelial transition factor (MET) has been implicated in several human cancers and is an attractive target for small molecule drug discovery. Herein, we report the discovery of compound 23 (AMG 337), which demonstrates nanomolar inhibition of MET kinase activity, desirable preclinical pharmacokinetics, significant inhibition of MET phosphorylation in mice, and robust tumor growth inhibition in a MET-dependent mouse efficacy model.
