129488-73-9

Basic information

• Product Name: methyl 4-(2-cyanopropan-2-yl)benzoate
• Synonyms: methyl 4-(2-cyanopropan-2-yl)benzoate;4-(Cyano-dimethyl-methyl)-benzoic acid methyl ester
• CAS NO: 129488-73-9
• Molecular Formula: C12H13NO2
• Molecular Weight: 203.23712
• Mol File: 129488-73-9.mol
• Article Data: 7

Chemical Properties

• Melting Point: 45-50 °C
• Boiling Point: 323.0±25.0 °C(Predicted)
• Appearance: /
• Density: 1.084±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: methyl 4-(2-cyanopropan-2-yl)benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 4-(2-cyanopropan-2-yl)benzoate(129488-73-9)
• EPA Substance Registry System: methyl 4-(2-cyanopropan-2-yl)benzoate(129488-73-9)

Safety Data

• Hazardous Substances Data: 129488-73-9(Hazardous Substances Data)

Upstream product

• 3609-53-8 methyl 4-acetylbenzoate 
• 26581-23-7 4-(1-methylethenyl)benzoic acid methyl ester 
• 75-86-5 2-hydroxy-2-methylpropanenitrile 
• 76469-88-0 methyl 4-(cyanomethyl)benzoate 
• 77-78-1 dimethyl sulfate 
• 851233-80-2 potassium 2-cyano-2-methyl-propanoate 
• 17763-71-2 4-carbomethoxyphenyl triflate 
• 74-88-4 methyl iodide 

Relevant articles and documents

Synthesis of Tertiary Benzylic Nitriles via Nickel-Catalyzed Markovnikov Hydrocyanation of α-Substituted Styrenes

The Markovnikov hydrocyanation of α-substituted styrenes enables the synthesis of tertiary benzylic nitriles under nickel catalysis. The Lewis-acid-free transformation features an unprecedented functional groups tolerance, including the-OH and-NH2 groups. A broad range of tertiary benzylic nitriles were obtained in good to excellent yields. In addition, an asymmetric version of this reaction was preliminarily investigated.

Synthesis of α-Aryl nitriles through palladium-catalyzed decarboxylative coupling of cyanoacetate salts with aryl halides and triflates

Worth its salt: The palladium-catalyzed decarboxylative coupling of the cyanoacetate salt as well as its mono- and disubstituted derivatives with aryl chlorides, bromides, and triflates is described (see scheme). This reaction is potentially useful for the preparation of a diverse array of α-aryl nitriles and has good functional group tolerance. S-Phos=2-(2,6- dimethoxybiphenyl)dicyclohexylphosphine), Xant-Phos=4,5-bis(diphenylphosphino)- 9,9-dimethylxanthene. Copyright

HETEROARYL COMPOUNDS AS DGAT-1 1NHIBITORS

The present invention relates to novel heteroaryl compounds, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of diseases or disorders mediated by Diacylglycerol acyltransferase (DGAT) enzyme, particularly DGAT- 1.