26581-23-7

Upstream product

• 187737-37-7 propene 
• 20883-45-8 4-methoxycarbonyl-phenylmercury ⁽¹⁺⁾; chloride 
• 7647-01-0 hydrogenchloride 
• 67-56-1 methanol 
• 3609-50-5 4-(2-hydroxypropan-2-yl)benzoic acid 
• 74-88-4 methyl iodide 
• 108-22-5 Isopropenyl acetate 
• 1126-46-1 Methyl 4-chlorobenzoate 
• 3609-53-8 methyl 4-acetylbenzoate 
• 2065-66-9 methyl-triphenylphosphonium iodide 
• 75-24-1 trimethylaluminum 
• 7377-26-6 4-Methoxycarbonylbenzoyl chloride 
• 1830-69-9 4-(prop-1-en-2-yl)benzoic acid 
• 18107-18-1 diazomethyl-trimethyl-silane 

Downstream Products

• 153881-24-4 4-(1-Formyl-vinyl)-benzoic acid methyl ester 
• 131170-40-6 2-methyl-4-(1-methylcyclopropyl)benzoic acid 
• 1622303-33-6 N-(3-bromo-2-(((tert-butyldimethylsilyl)oxy)methyl)phenyl)-4-(1-methylcyclopropyl)benzamide 
• 1622303-32-5 methyl 4-(1-methylcyclopropyl)benzoate 
• 3609-53-8 methyl 4-acetylbenzoate 
• 205489-38-9 4-(2-Hydroxy-1-methylene-4-phenyl-pent-4-enyl)-benzoic acid methyl ester 
• 153881-20-0 4-(2-Hydroxy-1-methylene-4-phenyl-pent-4-enyl)-benzoic acid 
• 240407-05-0 C₁₂H₁₄O₃ 
• 129488-73-9 methyl 4-(1-cyano-1-methylethyl)-benzoate 

Relevant academic research and scientific papers

Electrochemical fluorosulfonylation of alkenes to access vicinal fluorinated sulfones derivatives

Herein, we report a practical and efficient fluorosulfonylation of the various alkenes with sulfonyl radical sources (RSO2NHNH2) and Et3N·3HF as cost-effective fluorination reagents under mild conditions. Remarkably, this

Synthesis of Tertiary Benzylic Nitriles via Nickel-Catalyzed Markovnikov Hydrocyanation of α-Substituted Styrenes

The Markovnikov hydrocyanation of α-substituted styrenes enables the synthesis of tertiary benzylic nitriles under nickel catalysis. The Lewis-acid-free transformation features an unprecedented functional groups tolerance, including the-OH and-NH2 groups. A broad range of tertiary benzylic nitriles were obtained in good to excellent yields. In addition, an asymmetric version of this reaction was preliminarily investigated.

Palladium/Acid Relay Catalyzed Tandem Heck Coupling/6-Endo Cyclization between ortho-Halogenated Benzoates and Unactivated Terminal Alkenes for the Synthesis of 1-Isochromanones

We report a unique and expeditious route to synthesize 1-isochromanone derivatives through palladium catalyzed tandem Heck coupling/6-endo hydroacyloxylation cyclization between readily available ortho-halogenated benzoates and unactivated alkenes. Various 2-bromo or 2-iodo benzoates can be coupled efficiently with a broad range of alkenes to afford functionalized 1-isochromanones in high yields. Significantly, this cost-efficient and easy-to-handle synthetic methodology will have great prospect application in the synthetic and medicinal chemistry. (Figure presented.).

P300/CBP HAT INHIBITORS

Provided are compounds of Formula (I): and pharmaceutically acceptable salts and compositions thereof, which are useful for treating a variety of conditions associated with histone acetyltransferase (HAT).

Synthesis of 2-Substituted Propenes by Bidentate Phosphine-Assisted Methylenation of Acyl Fluorides and Acyl Chlorides with AlMe3

Bidentate phosphine-assisted methylenation of acyl fluorides and acyl chlorides with substituted with aryl, alkenyl, and alkyl groups trimethylaluminum afforded an array of 2-substituted propene derivatives. The addition of a catalytic amount of DPPM increased an efficiency of the reactions. Trimethylaluminum as the methylenation reagent not only eliminates the presynthesis of methylene transfer reagent, but provides an efficient method for the synthesis of a series of 2-substituted propenes.

Visible light-promoted dihydroxylation of styrenes with water and dioxygen

An efficient visible light promoted metal-free dihydroxylation of styrenes with water and dioxygen has been developed for the construction of vicinal alcohols. The protocol was operationally simple with a broad substrate scope. The mechanistic studies demonstrated that one of the hydroxyl groups came from water and the other one came from molecular oxygen. Additionally, the β-alkyoxy alcohols could also be obtained using a similar strategy.

Visible-Light-Driven Carboxylation of Aryl Halides by the Combined Use of Palladium and Photoredox Catalysts

A highly useful, visible-light-driven carboxylation of aryl bromides and chlorides with CO2 was realized using a combination of Pd(OAc)2 as a carboxylation catalyst and Ir(ppy)2(dtbpy)(PF6) as a photoredox catalyst. This carboxylation reaction proceeded in high yields under 1 atm of CO2 with a variety of functionalized aryl bromides and chlorides without the necessity of using stoichiometric metallic reductants.

SUBSTITUTED 1H-PYRROLOPYRIDINONE DERIVATIVES AS KINASE INHIBITORS

The present invention provides novel substituted 1H-Pyrrolopyridinone derivatives of formula (1) as protein kinase inhibitors, in which R1, R2, R3, R4, R5, R6 and 'p' have the meanings given in the specification, and pharmaceutically acceptable salts thereof that are useful in the treatment and prevention in diseases or disorder, in particular their use in diseases or disorder where there is an advantage in inhibiting kinase enzyme, more particularly BTK enzyme. The present invention also provides methods for synthesizing and administering the kinase inhibitor compounds. The present invention also provides pharmaceutical formulations comprising at least one of the kinase inhibitor compounds together with a pharmaceutically acceptable carrier, diluent or excipient therefor.

Photodecarbonylation of ketodiacids as ammonium salts: efficient Formation of C-C bonds between adjacent quaternary centers in the crystalline state

Here we report the crystallization and solid photochemistry of six quaternary ammonium salts of 2,4-di-p-carboxyphenyl-2,4-dimethyl pentanone. While salt formation resulted in solids with different melting temperatures and crystallinities, photochemical e

Cobalt-catalyzed vinylation of functionalized aryl halides with vinyl acetates

A new method for the preparation of styrene derivatives is described on the basis of the activation of aryl halides by low-valent cobalt species. A combination of CoII bromide and 2,2′-bipyridine is suitable as catalyst for the cross-coupling reaction of a wide range of aromatic halides (X = Cl, Br, I), mostly bearing sensitive moieties, with vinyl acetates. These reactions proceed under mild conditions in the presence of the appropriate reducing agent to afford α-substituted styrene compounds in satisfactory to high yields. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005.