1295561-37-3Relevant academic research and scientific papers
Lewis Acid Catalyzed Electrophilic Aminomethyloxygenative Cyclization of Alkynols with N, O-Aminals
Chen, Anrong,Yu, Houjian,Yan, Jiaqi,Huang, Hanmin
, p. 755 - 759 (2020/01/28)
Lewis acid enables the electrophilic carbooxygenative cyclization of alkynols with N,O-aminals. The new process proceeds efficiently under very mild conditions via a pathway that is opposite to classical carbo-metalation. These reactions exhibit broad substrate generality and functional group compatibility, leading to a wide variety of 5-8-membered oxacycles bearing diverse functional groups. The cyclization products can be elaborated via simple functional group transformations to generate synthetically useful oxacycles.
Regiocontrolled palladium-catalyzed arylative cyclizations of alkynols
Fujino, Daishi,Yorimitsu, Hideki,Osuka, Atsuhiro
, p. 6255 - 6258 (2014/05/20)
Tuning the reactivity of arylpalladium intermediates enables control of catalytic arylative 5-exo and 6-endo cyclizations of alkynols. The two modes of cyclizations represent a rare example of controllable, regioselective difunctionalization of alkynes. T
Regio- and stereoselective synthesis of 2-amino-1,3-diene derivatives by ruthenium-catalyzed coupling of ynamides and ethylene
Saito, Nozomi,Saito, Keiichi,Shiro, Motoo,Sato, Yoshihiro
supporting information; experimental part, p. 2718 - 2721 (2011/06/27)
A ruthenium-catalyzed hydrovinylation-type cross-coupling of ynamides and ethylene proceeds via ruthenacyclopentene to give 2-aminobuta-1,3-diene derivatives in a highly regioselective manner. It was also demonstrated that 2-aminobuta-1,3-diene derivatives reacted with various dienophiles or singlet oxygen to give a cyclic enamide derivative.
