129560-03-8

Basic information

• Product Name: 4-(4-methylphenoxy)-Benzenemethanamine
• Synonyms: 4-(4-methylphenoxy)-Benzenemethanamine;BenzeneMethanaMine, 4-(4-Methylphenoxy)-
• CAS NO: 129560-03-8
• Molecular Formula: C₁₄H₁₅NO
• Molecular Weight: 213.28
• Mol File: 129560-03-8.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4-(4-methylphenoxy)-Benzenemethanamine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-methylphenoxy)-Benzenemethanamine(129560-03-8)
• EPA Substance Registry System: 4-(4-methylphenoxy)-Benzenemethanamine(129560-03-8)

Safety Data

• Hazardous Substances Data: 129560-03-8(Hazardous Substances Data)

Usage

General Description

4-(4-methylphenoxy)-Benzenemethanamine is a chemical compound that belongs to the class of aromatic amines. It consists of a benzene ring with a methanamine group and a 4-(4-methylphenoxy) substituent. 4-(4-methylphenoxy)-Benzenemethanamine is commonly used in the synthesis of pharmaceuticals and is known for its potential biological activity. It has been studied for its potential as an antipsychotic and analgesic agent, as well as for its use in the treatment of neurodegenerative disorders. Additionally, the compound has been evaluated for its potential as an anti-cancer agent. However, further research is needed to fully understand its properties and potential uses.

Upstream product

• 623-03-0 4-Cyanochlorobenzene 
• 1192-96-7 potassium p-cresolate 
• 37563-42-1 4-(4'-methylphenoxy)benzonitrile 
• 1194-02-1 4-fluorobenzonitrile 
• 106-44-5 p-cresol 

Downstream Products

• 1185088-71-4 N-[4-(4-methylphenyloxy)phenyl]methyl-2-aminonicotinic acid amide 
• 1185089-98-8 N-[4-(4-methylphenyloxy)phenyl]methyl-2-amino-6-methylnicotinic acid amide 
• 262862-66-8 4-(4-methylphenoxy)benzylamine hydrochloride 
• 129558-76-5 N-[4-(4-methylphenoxy)benzyl]-4-chloro-3-ethyl-1-methyl-5-pyrazolecarboxamide 

Relevant articles and documents

Preparation method of substituted phenoxy benzylamine compound and preparation method of pyrazole carboxamide compound

The invention discloses a preparation method of a substituted phenoxy benzylamine compound. P-halobenzonitrile is taken as an initial raw material, R'OH is taken as a solvent in the presence of R'OM, the substituted phenoxy benzylamine compound is obtained through hydrogen reduction, and the preparation method has the advantages of high yield and high purity. The invention also discloses a preparation method of pyrazole carboxamide. The preparation method of pyrazole carboxamide comprises the following steps: salifying the substituted phenoxy benzylamine compound, and reacting with a substituted pyrazole acyl chloride compound to prepare the pyrazole carboxamide compound at an expected high yield. The preparation methods provided by the invention have the advantages of high product purity, high yield, low solvent loss and low production cost.

Structure-Activity Relationship Studies of Tolfenpyrad Reveal Subnanomolar Inhibitors of Haemonchus contortus Development

Recently, we have discovered that the registered pesticide, tolfenpyrad, unexpectedly and potently inhibits the development of the L4 larval stage of the parasitic nematode Haemonchus contortus with an IC50 value of 0.03 μM while displaying good selectivity, with an IC50 of 37.9 μM for cytotoxicity. As a promising molecular template for medicinal chemistry optimization, we undertook anthelmintic structure-activity relationships for this chemical. Modifications of the left-hand side (LHS), right-hand side (RHS), and middle section of the scaffold were explored to produce a set of 57 analogues. Analogues 25, 29, and 33 were shown to be the most potent compounds of the series, with IC50 values at a subnanomolar level of potency against the chemotherapeutically relevant fourth larval (L4) stage of H. contortus. Selected compounds from the series also showed promising activity against a panel of other different parasitic nematodes, such as hookworms and whipworms.