129574-22-7Relevant academic research and scientific papers
Regiochemistry in aryl radical cyclisations (5-exo versus 6-endo) of N-vinylic 2-iodobenzamides
Ishibashi, Hiroyuki,Ohata, Kohei,Niihara, Michiyo,Sato, Tatsunori,Ikeda, Masazumi
, p. 547 - 554 (2007/10/03)
Bu3SnH-mediated aryl radical cyclisations of a range of N-vinylic 2-iodobenzamides 10 were examined. The enamides 10a-d gave exclusively the 5-exo cyclisation products 11a-d, whereas the enamides 10e,f having a phenyl substituent on the vinylic carbon ato
Isoquinoline frameworks via aryl radical-initiated 1,6-cyclization
Takano,Suzuki,Kijima,Ogasawara
, p. 2315 - 2318 (2007/10/02)
Exclusive 1,6-cyclization occurred to afford isoquinoline frameworks when the enamide and the enamine substrates bearing exo-olefin moiety were treated with tri-n-butyltin hydride in the presence of radical initiator (9a, b → 12a, b; 13a, b → 18a, b), respectively. On the other hand, competitive 1,6- and 1,5-cyclization occurred to give a mixture of isoquinolone and isoindolone frameworks when the enamide substrates bearing endo-olefin moiety were treated under the same conditions (22a, b → 26a, b and 27a, b).
