129596-39-0Relevant academic research and scientific papers
Anti-Helicobacter pylori agents. 1. 2-(Alkylguanidino)-4-furylthiazoles and related compounds
Katsura, Yousuke,Tomishi, Tetsuo,Inoue, Yoshikazu,Sakane, Kazuo,Matsumoto, Yoshimi,Ishikawa, Hirohumi,Takasugi, Hisashi
, p. 2462 - 2465 (1997)
A series of 2-(alkylguanidino)-4-[5-(acetamidomethyl)furan-2- yl]thiazoles and related compounds were synthesized and evaluated for antimicrobial activity against Helicobacter pylori, inhibitory effect on gastric acid secretion, and histamine H2/sub
Anti-Helicobacter pylori agents. 2. Structure activity relationships in a new series of 2-alkylguanidino-4-furylthiazoles
Katsura, Yousuke,Nishino, Shigetaka,Tomishi, Tetsuo,Sakane, Kazuo,Matsumoto, Yoshimi,Ishikawa, Hirohumi,Takasugi, Hisashi
, p. 1307 - 1312 (1998)
SAR for antimicrobial activity against H. pylori was investigated in a new series of 2-alkylguanidino-4-furylthiazoles. Of the compounds obtained, cyclohexylmethyl and ethoxyethyl derivatives were identified as a novel class of anti-H. pylori agents which possessed potent and selective antimicrobial activity against H. pylori. These compounds also showed gastric antisecretory activity.
