129599-84-4

Upstream product

• 129704-70-7 2,2,2-Trichloro-acetimidic acid (Z)-(S)-4-fluoro-6-phenyl-5-(2,2,2-trichloro-acetylamino)-hex-3-enyl ester 
• 132549-51-0 2,2,2-Trichloro-acetimidic acid (Z)-(R)-2-fluoro-4-phenyl-1-[2-(2,2,2-trichloro-acetimidoyloxy)-ethyl]-but-2-enyl ester 
• 129704-73-0 N-((Z)-(S)-1-Benzyl-2-fluoro-5-hydroxy-pent-2-enyl)-2,2,2-trichloro-acetamide 
• 129704-64-9 (Z)-(S)-5-tert-Butoxycarbonylamino-4-fluoro-6-phenyl-hex-3-enoic acid 
• 129704-75-2 ((Z)-(S)-1-Benzyl-2-fluoro-5-hydroxy-pent-2-enyl)-carbamic acid tert-butyl ester 
• 129704-78-5 (Z)-(R)-4-Fluoro-3-hydroxy-6-phenyl-hex-4-enoic acid tert-butyl ester 
• 129704-77-4 (Z)-(R)-4-Fluoro-6-phenyl-hex-4-ene-1,3-diol 
• 934671-94-0 (Z)-(S)-5-Amino-4-fluoro-6-phenyl-hex-3-en-1-ol 
• 955038-33-2 (E)-Ethyl-2-fluoro-4-phenyl-2-butenoate 
• 132584-55-5 (Z)-2-Fluoro-4-phenyl-but-2-enal 
• 82911-69-1 N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide 
• 879220-74-3 (Z)-(S)-5-Amino-4-fluoro-6-phenyl-hex-3-enoic acid 

Relevant academic research and scientific papers

Diastereomeric fluoroolefins as peptide bond mimics prepared by asymmetric reductive amination of α-fluoroenones

(Chemical Equation Presented) Fluoropeptidomimetics: An efficient asymmetric reductive amination of fluoroenones has been developed that affords potential precursors of fluoropeptide isosteres. Stereoselective routes with different reductive agents provid

Fluoroolefin dipeptide isosteres - II. Enantioselective synthesis of both antipodes of the Phe-Gly dipeptide mimic

The addition of optically active ester enolatas to α-fluoro-α,β-unsaturated aldehydes and formal SN2′ substitution of an allylic hydroxyl group thus formed by a trichloro-acetamido group via Overman rearrangement constitutes a new general route to fluoroofefin dipeptide isosteres in enantiomerically pure form. This methodology was applied for the preparation of both enantiomars of the Phe...(CF=CH)Gly dipeptide mimic which were further elongated to substance P analogues.