1296172-85-4Relevant academic research and scientific papers
Iron-Catalyzed Nucleophilic Addition Reaction of Organic Carbanion Equivalents via Hydrazones
Li, Chen-Chen,Dai, Xi-Jie,Wang, Haining,Zhu, Dianhu,Gao, Jian,Li, Chao-Jun
supporting information, p. 3801 - 3805 (2018/07/25)
Earth-abundant and well-defined iron complexes are found to be cheap and effective catalysts for a series of "umpolung" nucleophilic additions of hydrazones. The new catalytic system not only maintains the broad substrate scope of an earlier expensive ruthenium system but also attains chemoselectivity of different kinds of carbonyl groups. Furthermore, the iron catalyst enables this reaction at ambient temperature.
Aldehydes as alkyl carbanion equivalents for additions to carbonyl compounds
Wang, Haining,Dai, Xi-Jie,Li, Chao-Jun
, p. 374 - 378 (2017/04/03)
Nucleophilic addition reactions of organometallic reagents to carbonyl compounds for carbon-carbon bond construction have played a pivotal role in modern chemistry. However, this reaction's reliance on petroleum-derived chemical feedstocks and a stoichiometric quantity of metal have prompted the development of many carbanion equivalents and catalytic metal alternatives. Here, we show that naturally occurring carbonyls can be used as latent alkyl carbanion equivalents for additions to carbonyl compounds, via reductive polarity reversal. Such 'umpolung' reactivity is facilitated by a ruthenium catalyst and diphosphine ligand under mild conditions, delivering synthetically valuable secondary and tertiary alcohols in up to 98% yield. The unique chemoselectivity exhibited by carbonyl-derived carbanion equivalents is demonstrated by their tolerance to protic reaction media and good functional group compatibility. Enantioenriched tertiary alcohols can also be accessed with the aid of chiral ligands, albeit with moderate stereocontrol. Such carbonyl-derived carbanion equivalents are anticipated to find broad utility in chemical bond formation.
Thermally Induced Carbohydroxylation of Styrenes with Aryldiazonium Salts
Kindt, Stephanie,Wicht, Karina,Heinrich, Markus R.
supporting information, p. 8744 - 8747 (2016/07/21)
The radical carbohydroxylation of styrenes with aryldiazonium salts has been achieved under mild thermal conditions. A broad range of aryldiazonium salts was tolerated, and the reaction principle based on a radical–polar crossover mechanism could be exten
A mild oxidative aryl radical addition into alkenes by aerobic oxidation of arylhydrazines
Taniguchi, Tsuyoshi,Zaimoku, Hisaaki,Ishibashi, Hiroyuki
experimental part, p. 4307 - 4312 (2011/05/07)
A mild and practical oxyarylation of alkenes by oxidative radical addition has been developed by using aerobic oxidation of hydrazine compounds. The use of a catalytic amount of potassium ferrocyanide trihydrate (K4[Fe(CN) 6]·3 H2O) and water accelerated this radical reaction to give peroxides or alcohols from simple alkenes in good yields. The environmentally friendly and economical radical reactions were achieved at room temperature in the presence of iron catalyst, oxygen gas, and water. A method involving aniline as a radical precursor is also described. Copyright
