1296201-74-5

Basic information

• Product Name: C₁₈H₁₇BrN₂O₂
• CAS NO: 1296201-74-5
• Molecular Weight: 373.249
• Mol File: 1296201-74-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₈H₁₇BrN₂O₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₈H₁₇BrN₂O₂(1296201-74-5)
• EPA Substance Registry System: C₁₈H₁₇BrN₂O₂(1296201-74-5)

Safety Data

• Hazardous Substances Data: 1296201-74-5(Hazardous Substances Data)

Upstream product

• 16732-65-3 6-bromo-indole-2-carboxylic acid(Ref_.7.) 
• 41789-95-1 1-(3-methoxyphenyl)-N-methylmethanamine 

Downstream Products

• 1296199-26-2 N-(3-methoxybenzyl)-N,1-dimethyl-6-(1H-pyrazol-4-yl)-1H-indole-2-carboxamide 
• 1296199-28-4 1-(2-(dimethylamino)ethyl)-N-(3-methoxybenzyl)-N-methyl-6-(1H-pyrazol-4-yl)-1H-indole-2-carboxamide 
• 1296201-85-8 C₂₂H₂₆BrN₃O₂ 
• 1296201-84-7 C₁₉H₁₉BrN₂O₂ 
• 1296199-12-6 N-(3-methoxybenzyl)-N-methyl-6-(1H-pyrazol-4-yl)-1H-indole-2-carboxamide 

Relevant articles and documents

Discovery and optimization of indole and 7-azaindoles as Rho kinase (ROCK) inhibitors (Part-II)

Therapeutic interventions with Rho kinase (ROCK) inhibitors may effectively treat several disorders such as hypertension, stroke, cancer, and glaucoma. Herein we disclose the optimization and biological evaluation of potent novel ROCK inhibitors based on substituted indole and 7-azaindole core scaffolds. Substitutions on the indole C3 position and on the indole NH and/or amide NH positions all yielded potent and selective ROCK inhibitors (25, 42, and 50). Improvement of aqueous solubility and tailoring of in vitro and in vivo DMPK properties could be achieved through these substitutions.