16732-65-3

Basic information

• Product Name: 6-Bromoindole-2-carboxylic acid
• Synonyms: 1H-INDOLE-2-CARBOXYLIC ACID, 6-BROMO-;AKOS JY2083011;6-BROMOINDOLE-2-CARBOXYLIC ACID;6-BROMO-1H-INDOLE-2-CARBOXYLIC ACID;6-BROMO-2-INDOLECARBOXYLIC ACID;6-BROMOINDOLE-2-CARBOXYLIC ACID 98%;Bromoindole-2-carboxylic acid;6-Bromoindole-2-carboxylic acid ,99%
• CAS NO: 16732-65-3
• Molecular Formula: C₉H₆BrNO₂
• Molecular Weight: 240.05
• Product Categories: Indole/indoline/oxindole;Indole and Indoline;Indoles and derivatives;Indole;Indoles
• Mol File: 16732-65-3.mol
• Article Data: 4

Chemical Properties

• Melting Point: 221-223°C
• Boiling Point: 470.9 °C at 760 mmHg
• Flash Point: 238.6 °C
• Appearance: /Solid
• Density: 1.838 g/cm³
• Vapor Pressure: 1.13E-09mmHg at 25°C
• Refractive Index: 1.749
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 4.30±0.30(Predicted)
• CAS DataBase Reference: 6-Bromoindole-2-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Bromoindole-2-carboxylic acid(16732-65-3)
• EPA Substance Registry System: 6-Bromoindole-2-carboxylic acid(16732-65-3)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 36/37/39
• HazardClass: IRRITANT
• Hazardous Substances Data: 16732-65-3(Hazardous Substances Data)

Usage

Chemical Properties

Light yellow powder

InChI:InChI=1/C9H6BrNO2/c10-6-2-1-5-3-8(9(12)13)11-7(5)4-6/h1-4,11H,(H,12,13)

Upstream product

• 103858-53-3 ethyl 6-bromo-1H-indole-2-carboxylate 
• 99365-39-6 3-(4-bromo-2-nitrophenyl)-2-oxopropanoic acid 

Downstream Products

• 79878-02-7 1-(6-bromo-1H-indol-3-yl)-2,2,2-trifluoroethan-1-one 
• 923197-75-5 (6-bromo-1H-indol-2-yl)methanol 
• 103858-53-3 ethyl 6-bromo-1H-indole-2-carboxylate 
• 1382774-46-0 4-(4-fluorophenethyl)-1-(1,1,5-trimethyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indol-7-yl)piperazin-2-one 
• 1382774-64-2 tert-Butyl 7-(4-(4-fluorophenethyl)-2-oxopiperazin-1-yl)-1,1,5-trimethyl-3,4-dihydro-1H-pyrido[4,3-b]indole-2(5H)-carboxylate 
• 1296201-74-5 C₁₈H₁₇BrN₂O₂ 
• 1296201-85-8 C₂₂H₂₆BrN₃O₂ 
• 1296201-84-7 C₁₉H₁₉BrN₂O₂ 
• 1296199-28-4 1-(2-(dimethylamino)ethyl)-N-(3-methoxybenzyl)-N-methyl-6-(1H-pyrazol-4-yl)-1H-indole-2-carboxamide 
• 1296201-83-6 C₂₁H₂₄BrN₃O₂ 
• 1296201-82-5 C₂₀H₂₁BrN₂O₃ 
• 1296199-26-2 N-(3-methoxybenzyl)-N,1-dimethyl-6-(1H-pyrazol-4-yl)-1H-indole-2-carboxamide 
• 1296199-12-6 N-(3-methoxybenzyl)-N-methyl-6-(1H-pyrazol-4-yl)-1H-indole-2-carboxamide 
• 1296199-34-2 3-((1,4-diazepan-1-yl)methyl)-N-(3-methoxybenzyl)-6-(1H-pyrazol-4-yl)-1H-indole-2-carboxamide 

Relevant articles and documents

Synthesis, structure-activity relationship and antiviral activity of indole-containing inhibitors of Flavivirus NS2B-NS3 protease

Zika virus belongs to the Flavivirus family of RNA viruses, which include other important human pathogens such as dengue and West Nile virus. There are no approved antiviral drugs for these viruses. The highly conserved NS2B-NS3 protease of Flavivirus is essential for the replication of these viruses and it is therefore a drug target. Compound screen followed by medicinal chemistry optimization yielded a novel series of 2,6-disubstituted indole compounds that are potent inhibitors of Zika virus protease (ZVpro) with IC50 values as low as 320 nM. The structure-activity relationships of these and related compounds are discussed. Enzyme kinetics studies show the inhibitor 66 most likely exhibited a non-competitive mode of inhibition. In addition, this series of ZVpro inhibitors also inhibit the NS2B-NS3 protease of dengue and West Nile virus with reduced potencies. The most potent compounds 66 and 67 strongly inhibited Zika virus replication in cells with EC68 values of 1–3 μM. These compounds are novel pharmacological leads for further drug development targeting Zika virus.

INHIBITORS OF THE MENIN-MLL INTERACTION

The present invention is directed to inhibitors of the interaction of menin with MLL and MLL fusion proteins, pharmaceutical compositions containing the same, and their use in the treatment of cancer and other diseases mediated by the menin-MLL interaction.