129623-80-9

Upstream product

• 146850-30-8 tert-butyl 4-(4-hydroxy-1-butenyl)benzoate 
• 65874-27-3 4-(tert-butoxycarbonyl)benzaldehyde 
• 193265-42-8 1,1-dimethylethyl 4-(4-hydroxy-1-butyn-1-yl)benzoate 

Downstream Products

• 146850-31-9 tert-butyl 4-(4-oxobutyl)benzoate 
• 129623-79-6 4-[(4-tert-butoxycarbonyl)phenyl]butyl methanesulfonate 
• 125991-54-0 diethyl N-<4-<3-(2-amino-4(3H)-oxo-7H-pyrrolo<2,3-d>pyrimidin-5-yl)propyl>benzoyl>-L-glutamate 
• 146943-42-2 tert-butyl 4-<4-(2,6-diamino-4(3H)-oxopyrimidin-5-yl)-5,5-dimethoxypentyl>benzoate 
• 134373-08-3 tert-butyl 4-<4-(2,4,6-triaminopyrimidin-5-yl)-5,5-dimethoxypentyl>benzoate 
• 144051-63-8 4-[3-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)propyl]benzoic acid 
• 134373-03-8 tert-butyl 4-<5,5-dicyano-4-(dimethoxymethyl)pentyl>benzoate 
• 134373-02-7 tert-butyl 4-(5-methoxy-4-pentenyl)benzoate 

Relevant academic research and scientific papers

PYRAZOLO[3,4-B]PYRIDINE COMPOUNDS, AND THEIR USE AS PDE4 INHIBITORS

The invention provides a compound of formula (I) or a salt thereof: wherein Ar has the sub-formula (x): and wherein: Q1 is NH or NMe, in which case Q2 is -C(O)-, -S(O)2-, -C(O)NH- or -C(O)NMe-; or Q1 is a bond o

A Novel Synthetic Approach to Pyrrolopyrimidine Antifolates

A novel and efficient synthetic method for the synthesis of pyrrolopyrimidine antifolates is described.The key reaction of this method is the photo-initiated free radical addition of bromomalononitrile or ethyl bromocyanoacetate to an enol ether to afford the backbone skeleton of the targeted antifolate molecule.The key intermediates 3 or 4 are smoothly converted to the pyrrolopyrimidine antifolates 1 or 2 in three steps and in high overall yield.