1296269-73-2

Upstream product

• 1296269-70-9 4-iodo-5-(methylthio)-1,3-diphenyl-1H-pyrazole 
• 5720-07-0 4-methoxyphenylboronic acid 
• 66040-87-7 1,3-diphenyl-5-(methylthio)-1H-pyrazole 
• 32859-25-9 4-bromo-5-(methylthio)-1,3-diphenyl-1H-pyrazole 

Downstream Products

• 1296269-91-4 4-(4-methoxyphenyl)-1,3-diphenyl-1H-pyrazole 

Relevant academic research and scientific papers

Mutant type IDH inhibitors, preparation method thereof, and pharmaceutical composition containg the same as an active ingredient

The present invention is a mutated IDH1 inhibitor. The present invention relates to a compound represented by chemical formula 1, a stereoisomer thereof, or a pharmaceutically acceptable salt thereof according to the present invention, which has excellent inhibitory activity against mutated IDH1 and can reduce intracellular tumor-induced metabolite (2-HG), and a health functional food composition for preventing or IDH1 treating cancer, comprising the same as an active ingredient.

Regioselective rapid analog synthesis of 1,3-(or 1,5-)diphenyl-4-aryl/ heteroaryl-5-(or 3-)(methylthio)pyrazoles via Suzuki cross-coupling

Regioselective routes for the synthesis of 1,3-(or 1,5-)diphenyl-4-aryl/ heteroaryl-5-(or 3-)(methylthio)pyrazoles via Suzuki cross-coupling of 4-bromo (or 4-iodo)-1,3-(or 1,5-)diphenyl-5-(or 3-)(methylthio)pyrazoles have been reported.