129664-47-7

Basic information

• Product Name: 1-<3,5-bis-O-(p-chlorobenzoyl)-2-deoxy-β-D-erythro-pentofuranosyl>-5-trifluoromethyluracil
• Synonyms: 1-<3,5-bis-O-(p-chlorobenzoyl)-2-deoxy-β-D-erythro-pentofuranosyl>-5-trifluoromethyluracil
• CAS NO: 129664-47-7
• Molecular Weight: 573.309
• Mol File: 129664-47-7.mol
• Article Data: 7

Chemical Properties

• Melting Point: 173-176 °C
• Density: 1.59±0.1 g/cm3(Predicted)
• CAS DataBase Reference: 1-<3,5-bis-O-(p-chlorobenzoyl)-2-deoxy-β-D-erythro-pentofuranosyl>-5-trifluoromethyluracil(CAS DataBase Reference)
• NIST Chemistry Reference: 1-<3,5-bis-O-(p-chlorobenzoyl)-2-deoxy-β-D-erythro-pentofuranosyl>-5-trifluoromethyluracil(129664-47-7)
• EPA Substance Registry System: 1-<3,5-bis-O-(p-chlorobenzoyl)-2-deoxy-β-D-erythro-pentofuranosyl>-5-trifluoromethyluracil(129664-47-7)

Safety Data

• Hazardous Substances Data: 129664-47-7(Hazardous Substances Data)

Usage

Chemical class

Derivative of uracil, a nucleobase in RNA

Structural features

Uracil base with two p-chlorobenzoyl groups attached to the 3 and 5 positions
2-deoxy-β-D-erythro-pentofuranosyl group attached to the 1 position
Trifluoromethyl group attached to the 5 position of the uracil base

Molecular weight

555.2 g/mol

Appearance

Likely a solid or crystalline compound, though specific appearance not provided

Solubility

Solvent compatibility not provided, but likely soluble in organic solvents due to the presence of aromatic and fluorinated groups

Stability

Stability not explicitly mentioned, but the compound's structure suggests it may be sensitive to hydrolysis or other degradation pathways

Medicinal chemistry interest

Potential antiviral properties

Therapeutic applications

Being explored as a potential treatment for certain viral infections

Unique properties

The combination of the uracil base, p-chlorobenzoyl groups, 2-deoxy-β-D-erythro-pentofuranosyl group, and trifluoromethyl group make this compound a unique and interesting candidate for further study and potential therapeutic applications.

Upstream product

• 3601-90-9 5-chloro-2-(((4-chlorobenzoyl)oxy)methyl)tetrahydrofuran-3-yl 4-chlorobenzoate 
• 7057-43-4 5-trifluoromethyl-2,4-bis(trimethylsilyloxy)pyrimidine 
• 54-20-6 5-trifluoromethyluracil 
• 21740-23-8 3,5-O-bis(4-chlorobenzoyl)-2-deoxy-α-D-ribofuranosyl chloride 
• 54-20-6 5-trifluoromethyluracil 

Downstream Products

• 70-00-8 2'-deoxy-5-trifluoromethyluridine 

Relevant articles and documents

THE SYNTHESIS OF 2'-DEOXY-5-TRIFLUOROMETHYLURIDINE UTILIZING A COUPLING REACTION

The coupling reaction between 1-α-chloro-2-deoxyribose derivative and silylated 5-trifluoromethyluracil was examined.The best stereoselectivity was obtained when the reaction was carried out using a large amount of silylated base in the presence of anhydrous zinc chloride.

METHOD FOR PREPARING TRIFLURIDINE

The present application relates to a method for preparing trifluridine, comprising reacting a compound of formula III with a compound of formula IV in a first solvent in the presence of an acid to obtain a compound of formula II, and performing further reaction to obtain trifluridine.

High purity qu Fu uridine preparation method (by machine translation)

The present invention provides a high purity qu Fu uridine preparation method, as the compound 2 as the raw material, with the first under the action of the HMDS in trimethylchlorosilane reaction to obtain compound 3, compound 3 with the raw material compound 4 in catalyst b fluorinated copper under the action of the condensation, of ethanol by recrystallization to obtain compound 5, the final compound 5 in the protection under the action of the sodium methoxide, through ethanol and acetone mixed solvent (1:1) by recrystallization to obtain a high purity of the target compound 1. The method of the invention, the resulting product has high purity, the method is simple, easy to be purified, industrial and less pollution. (by machine translation)